Plasma Levels of Receptor for Advanced Glycation End-Products and High-Mobility Group Box 1 in Patients With Pulmonary Hypertension
Plasma Levels of Receptor for Advanced Glycation End-Products and High-Mobility Group Box 1 in Patients With Pulmonary Hypertension
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DOI：
10.1536/ihj.15-188
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发表时间：
2016-03-01
影响因子：
1.5
通讯作者：
Takeishi, Yasuchika
中科院分区：
文献类型：
--
作者：
Suzuki, Satoshi;Nakazato, Kazuhiko;Takeishi, Yasuchika
肺动脉高压（PH）患者的肺动脉压升高导致右心室衰竭并最终死亡。高迁移率族蛋白1（HMGB 1）是一种核蛋白，通过激活细胞外环境中的晚期糖基化终产物受体（receptor for advanced glycation end-products，HMGB 1）而发挥促炎细胞因子的作用。为探讨肺动脉高压（PH）患者血浆中HMGB 1和可溶性β 2-D水平的临床意义，测定了27例PH患者（14例肺动脉高压（PAH），13例慢性血栓栓塞性肺动脉高压（CTEPH））和30例正常对照者血浆中HMGB 1和可溶性β 2-D水平。PH组与对照组血浆HMGB 1水平无差异。PH患者血浆可溶性肌酐水平显著高于对照组（P < 0.001）。PAH（P < 0.001）和CTEPH（P < 0.0001）的血浆可溶性RAGE水平高于对照组。此外，肺动脉压与血浆可溶性肌酐水平之间存在显著正相关（r = 0.403，P < 0.0001）。在CTEPH患者中，球囊肺血管成形术后可溶性肌酐水平降低（P < 0.001）。血浆可溶性HMGB 1水平可能是反映PH患者病理状态的一个新的标志物。
An increase of pulmonary artery pressure in patients with pulmonary hypertension (PH) results in right ventricular failure and ultimately death. High-mobility group box 1 (HMGB1), a nuclear protein, acts as a pro-inflammatory cytokine by activating receptor for advanced glycation end-products (RAGE) in the extracellular environment. The purpose of this study was to examine the clinical significance of circulating levels of HMGB1 and RAGE in patients with PH. Plasma levels of HMGB1 and soluble RAGE were measured in 27 patients with PH (14 with pulmonary arterial hypertension [PAH], 13 with chronic thromboembolic pulmonary hypertension [CTEPH]) and 30 normal subjects as control. There was no difference in the plasma levels of HMGB1 between the PH patients and the control subjects. However, plasma levels of soluble RAGE were significantly higher in the patients with PH than in the controls (P < 0.001). Plasma soluble RAGE levels were higher in PAH (P < 0.001) and CTEPH (P < 0.0001) than in the controls. In addition, there was a statistically significant positive correlation between pulmonary artery pressure and plasma levels of soluble RAGE (r = 0.403, P < 0.0001). In the CTEPH patients, soluble RAGE levels were reduced after balloon pulmonary angioplasty (P < 0.001). Plasma levels of soluble RAGE, but not HMGB1, might be a novel marker that reflects the pathological condition in patients with PH.