CDK9: A key player in cancer and other diseases
CDK9: A key player in cancer and other diseases
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DOI：
10.1002/jcb.26293
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发表时间：
2018-02-01
影响因子：
4
通讯作者：
Giordano, Antonio
中科院分区：
文献类型：
--
作者：
Carolina Franco, Lia;Morales, Fatima;Giordano, Antonio
细胞周期蛋白依赖性激酶9(CDK9)是一组功能多样的酶的一部分，负责细胞周期的控制和进展。它主要与Cyclin T1结合，形成正转录延伸因子b(p-TEFb)复合体，负责调节转录延伸和mRNA成熟。最近的研究强调了CDK9在许多相关病理过程中的重要性，如癌症、心血管疾病和病毒复制。在此，我们提供了CDK9直接和间接参与的不同途径的概述。
Cyclin-Dependent Kinase 9 (CDK9) is part of a functional diverse group of enzymes responsible for cell cycle control and progression. It associates mainly with Cyclin T1 and forms the Positive Transcription Elongation Factor b (p-TEFb) complex responsible for regulation of transcription elongation and mRNA maturation. Recent studies have highlighted the importance of CDK9 in many relevant pathologic processes, like cancer, cardiovascular diseases, and viral replication. Herein we provide an overview of the different pathways in which CDK9 is directly and indirectly involved.