Correlation Between Expression of the Cancer/Testis Antigen KK-LC-1 and Helicobacter pylori Infection in Gastric Cancer
Correlation Between Expression of the Cancer/Testis Antigen KK-LC-1 and Helicobacter pylori Infection in Gastric Cancer
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DOI：
10.21873/invivo.11073
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发表时间：
2017-05-01
期刊：
影响因子：
2.3
通讯作者：
Kobayashi, Noritada
中科院分区：
文献类型：
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作者：
Fukuyama, Takashi;Futawatari, Nobue;Kobayashi, Noritada
背景/目的：我们以前的研究表明，北九州肺癌抗原-1（KK-LC-1）是一种癌/睾丸抗原（CTA），在82%的胃癌病例中表达。在这里，我们研究了日本胃癌患者中KK-LC-1表达与幽门螺杆菌感染之间的关系。患者和方法：我们检测了25例手术切除的胃癌标本中CTA的表达和抗H。pylori IgG抗体。结果如下：KK-LC-1在80%的肿瘤标本中表达，明显高于黑色素瘤抗原基因（法师）-A1、MAGE-A3、MAGE-A4、滑膜肉瘤、X断裂点4（SSX 4）和纽约食管鳞状细胞癌-1（NY-ESO-1）。抗艾滋来自KK-LC-1阳性患者的pylori IgG滴度（67.5 ± 7.6）显著高于来自KK-LC-1阴性患者的pylori IgG滴度（15.8 ± 7.5，p
Background/Aim: Our previous study indicated that Kita-kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) expressed in 82% of gastric cancer cases. Here, we investigated the relationship between KK-LC-1 expression and Helicobacter pylori infection in Japanese patients with gastric cancer. Patients and Methods: We examined CTA expression in 25 surgical gastric cancer specimens and anti-H. pylori IgGs in the serum of each patient. Results: KK-LC-1 was expressed in 80% of tumor samples, markedly higher than melanoma antigen gene (MAGE)-A1, MAGE-A3, MAGE-A4, synovial sarcoma, X breakpoint 4 (SSX4) and New York esophageal squamous cell carcinoma-1 (NY-ESO-1). Anti-H. pylori IgG titers from the KK-LC-1-positive patients were significantly higher (67.5 +/- 7.6) than those from KK-LC-1-negative patients (15.8 +/- 7.5, p