Non-alcoholic fatty liver disease fibrosis score and FIB-4 scoring system could identify patients at risk of systemic complications
Non-alcoholic fatty liver disease fibrosis score and FIB-4 scoring system could identify patients at risk of systemic complications
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DOI：
10.1111/hepr.12405
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发表时间：
2015-06-01
影响因子：
4.2
通讯作者：
Izumi, Namiki
中科院分区：
文献类型：
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作者：
Takahashi, Yuka;Kurosaki, Masayuki;Izumi, Namiki
目的探讨非酒精性脂肪性肝病（NAFLD）的全身并发症与非侵袭性纤维化评分（NFS）和FIB-4之间的关系。结果1559例患者以NFS和FIB-4的低切值分为两组：第1组（低切值伴脂肪肝）和第2组（其他）。在第1组中，基线时糖尿病和心脑血管疾病的患病率以及观察期间的其他发病率均高于第2组。基线时糖尿病组1和组2分别为31.5%和3.1%（NFS，P
AimTo investigate the relation between systemic complications of non-alcoholic fatty liver disease (NAFLD) and non-invasive fibrosis scores.MethodsThe NAFLD fibrosis score (NFS) and FIB-4 were measured in 1559 people who underwent a complete medical checkup at our hospital and were followed for more than 3 years. Correlation between these scores and prevalence and new incidence rates of diabetes or cerebral-cardiovascular diseases were analyzed.ResultsThe 1559 cases were classified into two groups using the low cut-off values of NFS and FIB-4: group 1 (low cut-off score with fatty liver) and group 2 (the others). In group 1, the prevalence of diabetes and cerebral-cardiovascular diseases at baseline and additional incidences during the observation period was higher compared with group 2. Diabetes at baseline in group 1 versus group 2 were 31.5% versus 3.1% (NFS, P