Angiotensin-converting Enzyme Inhibitors Decrease the Risk of Cardiac Rupture after Acute Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials
Angiotensin-converting Enzyme Inhibitors Decrease the Risk of Cardiac Rupture after Acute Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials
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DOI：
10.15212/cvia.2023.0040
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发表时间：
2023
影响因子：
0.5
通讯作者：
Siyi Li;Jinan Wang;Yan Yan-Yan;W. Gong;S. Nie
中科院分区：
文献类型：
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作者：
Siyi Li;Jinan Wang;Yan Yan-Yan;W. Gong;S. Nie
背景：ACEI治疗可降低急性心肌梗死患者的死亡率。然而，ACEI对CR的影响尚不清楚。研究方法：对PUBMED、EMBASE、ISI Web of Science、MEDLINE和科克伦对照试验登记系统（2022年7月之前）进行了全面检索，以识别所有将CR记录为结局的ACEI RCT。使用Review Manager 5.3分析数据。结果如下：确定了5项RCT，包括26，383例MI患者; 13，159例接受ACEI的患者中有71例和13，224例对照患者中有107例被证实为CR。急性心肌梗死24小时内开始ACEI治疗可显著降低CR的风险，降低33%（RR：0.67，95% CI：0.50-0.90，P=0.008）。结论：急性心肌梗死患者早期（发病后24小时内）使用ACEI可降低CR的发生率。
Background: ACEI therapy decreases mortality in patients with acute MI. However, the effects of ACEIs on CR are unclear. Methods: A comprehensive search of PUBMED, EMBASE, ISI Web of Science, MEDLINE and the Cochrane Register of Controlled Trials before July 2022 was conducted to identify all RCTs on ACEIs that recorded CR as an outcome. Review Manager 5.3 was used to analyze the data. Results: Five RCTs including 26,383 patients with MI were identified; 71 of the 13,159 patients receiving ACEIs and 107 of the 13,224 control patients were verified to have CR. ACEI therapy started within 24 hours after the onset of acute MI significantly decreased the risk of CR, by 33% (RR: 0.67, 95% CI: 0.50–0.90, P=0.008). Conclusions: Early administration of ACEIs (within 24 hours after the onset of acute MI) decreased the incidence of CR in patients with acute MI.