Heart-Type Fatty Acid Binding Protein (H-FABP): Relationship with arterial intima-media thickness and role as diagnostic marker for atherosclerosis in patients with impaired glucose metabolism
Heart-Type Fatty Acid Binding Protein (H-FABP): Relationship with arterial intima-media thickness and role as diagnostic marker for atherosclerosis in patients with impaired glucose metabolism
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DOI：
10.1186/1475-2840-10-37
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发表时间：
2011-05-02
影响因子：
9.3
通讯作者：
Delibasi, Tuncay
中科院分区：
文献类型：
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作者：
Karbek, Basak;Ozbek, Mustafa;Delibasi, Tuncay
背景：在以往的研究中，心肌型脂肪酸结合蛋白(H-FABP)与急性冠脉综合征、心脏异常、中风和阻塞性睡眠障碍密切相关。研究设计与方法：采用双抗体夹心酶联免疫吸附试验检测58例糖尿病前期患者、29例空腹血糖受损(IFG)和29例糖耐量低减(IGT)患者以及28例年龄、性别和体重指数匹配的对照组血清H-FABP水平，并进行颈动脉内膜中层厚度(CIMT)测定。结果：糖尿病前期患者血清H-FABP水平显著高于对照组(IFG：32.5+/-34.2 ng/dL，IGT：45.4+/-45.8 ng/dL，对照组：16.8+/-14.9 ng/dL；P=0.011)。糖耐量低减或糖耐量低减患者与正常对照组的平均水平差异有统计学意义(p=0.010和p=0.009)。糖尿病前期组CIMT显著高于对照组(IFG0.6+/-0.1，IGT：0.6+/-0.1，对照组：0.5+/-0.1；p<；0.001)，且H-FABP水平与CIMT呈正相关(p<；0.001，Rho=0.626)。结论：糖尿病前期患者发生心血管疾病的风险增加。此外，血清H-FABP水平可作为IFG和IGT患者心肌功能的有用标记物。
Background: Heart type fatty acid binding protein (H-FABP) has been closely associated with acute coronary syndrome, cardiac abnormalities, stroke, and obstructive sleep disorder in previous studies. The aim of this study was to evaluate and compare the serum H-FABP levels and carotid artery intima-media thickness (CIMT) between patients with prediabetes and control subjects.Research design and methods: We measured serum H-FABP levels in 58 prediabetic patients, 29 with impaired fasting glucose (IFG) and 29 with impaired glucose tolerance (IGT) and 28 age-, sex-and body mass index-matched control subjects using a sandwich enzyme-linked immunosorbent assay (ELISA), and in order to measure CIMT, all participants underwent high-resolution B-mode ultrasonography.Results: Serum H-FABP levels were significantly elevated in pre-diabetic patients when compared with that of control subjects (IFG: 32.5 +/- 34.2 ng/dL, IGT: 45.4 +/- 45.8 ng/dL, control: 16.8 +/- 14.9 ng/dL; p = 0.011). The difference in means of H-FABP levels between patients with IGT or IFG and control subjects was significant (p = 0.010 and p = 0.009, respectively). CIMT was higher in the pre-diabetic groups compared with the control group (IFG: 0.6 +/- 0.1, IGT: 0.6 +/- 0.1, control: 0.5 +/- 0.1; p < 0.001), and H-FABP level was positively correlated with CIMT (p < 0.001, rho = 0.626).Conclusion: Our results indicate that patients with pre-diabetes are at increased risk for cardiovascular disease. In addition, serum H-FABP levels could represent a useful marker for myocardial performance in patients with IFG and IGT.