THE ROLE OF ENDOTOXIN FOR REACTIONS AFTER EXPOSURE TO COTTON DUST
THE ROLE OF ENDOTOXIN FOR REACTIONS AFTER EXPOSURE TO COTTON DUST
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DOI：
10.1002/ajim.4700120607
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发表时间：
1987-01-01
影响因子：
3.5
通讯作者：
RYLANDER, R
中科院分区：
文献类型：
--
作者：
RYLANDER, R
革兰氏阴性菌及其内毒素存在于棉花植株的所有部位，并在雨后或霜冻后大量出现。内毒素激活肺巨噬细胞，进而将中性粒细胞募集到气道中。血小板聚集在肺毛细血管中。这些细胞的存在允许急性和慢性炎症的起始。已证明内毒素与棉花工人发热、胸闷和气流减少（支气管收缩）之间存在剂量反应关系。有限的数据表明，棉尘暴露后，其他症状，如气道高反应性和慢性炎症，也与内毒素暴露有关。列出了气载内毒素的暂定阈值。
Gram‐negative bacteria and their endotoxins are present on all parts of the cotton plant and occur in large numbers after rain or frost. Endotoxins activate pulmonary macrophages that in turn recruit neutrophils into the airways. Platelets accumulate in pulmonary capillaries. The presence of these cells allows for the initiation of acute and chronic inflammation. Dose‐response relationships have been demonstrated between endotoxin and fever, chest tightness, and reduction in air flow (bronchoconstriction) in cotton workers. Limited data suggest that after cotton dust exposure, other symptoms, such as airway hyperreactivity and chronic inflammation, are also related to the endotoxin exposure. Tentative thresholds for airborne endotoxins are presented.