Advanced reconstructive technologies for periodontal tissue repair.

Advanced reconstructive technologies for periodontal tissue repair.
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DOI:
10.1111/j.1600-0757.2011.00432.x
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发表时间:
2012-06
影响因子:
18.6
通讯作者:
Giannobile WV
Giannobile WV
中科院分区:
医学1区
文献类型:
--
作者:
Ramseier CA;Rasperini G;Batia S;Giannobile WV

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通过临床前和临床研究,研究了促进牙周支持再生的重建疗法。利用新的屏障膜技术、细胞生长刺激蛋白或基因传递应用的先进再生技术已进入临床领域。使用生长因子修复牙齿支撑骨、牙周韧带和牙骨质的伤口愈合方法被证明可以显著促进牙周再生医学领域的发展。局部递送生长因子,如血小板衍生生长因子、成纤维细胞生长因子或骨形态发生蛋白,到牙周伤口已经显示出有希望的结果。未来的方向在传递生长因子或其他信号模型涉及创新的支架基质,细胞治疗和基因转移的发展,这些问题在本文中进行了讨论。
Reconstructive therapies to promote the regeneration of lost periodontal support have been investigated through both preclinical and clinical studies. Advanced regenerative technologies using new barrier‐membrane techniques, cell‐growth‐stimulating proteins or gene‐delivery applications have entered the clinical arena. Wound‐healing approaches using growth factors to target the restoration of tooth‐supporting bone, periodontal ligament and cementum are shown to significantly advance the field of periodontal‐regenerative medicine. Topical delivery of growth factors, such as platelet‐derived growth factor, fibroblast growth factor or bone morphogenetic proteins, to periodontal wounds has demonstrated promising results. Future directions in the delivery of growth factors or other signaling models involve the development of innovative scaffolding matrices, cell therapy and gene transfer, and these issues are discussed in this paper.
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