Coronavirus disease 2019 (COVID-19): current status and future perspectives
Coronavirus disease 2019 (COVID-19): current status and future perspectives
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DOI：
10.1016/j.ijantimicag.2020.105951
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发表时间：
2020-05-01
影响因子：
10.8
通讯作者：
Tang, Chao-Ke
中科院分区：
文献类型：
--
作者：
Li, Heng;Liu, Shang-Ming;Tang, Chao-Ke
冠状病毒病2019年(新冠肺炎)起源于湖北省武汉市中部中国，迄今已迅速传播至72个国家。新冠肺炎是由一种新的冠状病毒引起的，命名为严重急性呼吸综合征冠状病毒2(SARS-CoV-2)[以前暂时称为2019年新型冠状病毒(2019-NCoV)]。目前，新发现的SARS-CoV-2已造成全球数万确诊病例的大量死亡，对公众健康构成严重威胁。然而，目前还没有临床批准的疫苗或特定的治疗药物可用于新冠肺炎。迫切需要对新出现的SARS-CoV-2进行深入研究，以阐明其致病机制和流行病学特征，并确定潜在的药物靶点，这将有助于制定有效的预防和治疗策略。因此，本文将就SARS-CoV-2的结构和新冠肺炎的特性，如病原学、致病机理和流行病学特征等方面的研究进展作一综述。(C)2020 Elsevier B.V.和国际化疗学会。版权所有。
Coronavirus disease 2019 (COVID-19) originated in the city of Wuhan, Hubei Province, Central China, and has spread quickly to 72 countries to date. COVID-19 is caused by a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [previously provisionally known as 2019 novel coronavirus (2019-nCoV)]. At present, the newly identified SARS-CoV-2 has caused a large number of deaths with tens of thousands of confirmed cases worldwide, posing a serious threat to public health. However, there are no clinically approved vaccines or specific therapeutic drugs available for COVID-19. Intensive research on the newly emerged SARS-CoV-2 is urgently needed to elucidate the pathogenic mechanisms and epidemiological characteristics and to identify potential drug targets, which will contribute to the development of effective prevention and treatment strategies. Hence, this review will focus on recent progress regarding the structure of SARS-CoV-2 and the characteristics of COVID-19, such as the aetiology, pathogenesis and epidemiological characteristics. (C) 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.