White matter abnormalities in long-term anabolic-androgenic steroid users: A pilot study.
White matter abnormalities in long-term anabolic-androgenic steroid users: A pilot study.
复制标题
长期合成代谢 - 雄性类固醇使用者的白质异常：一项初步研究。
DOI：
10.1016/j.pscychresns.2016.12.003
复制
发表时间：
2017-02-28
期刊：
影响因子：
--
通讯作者：
Kaufman MJ
中科院分区：
文献类型：
--
作者：
Seitz J;Lyall AE;Kanayama G;Makris N;Hudson JI;Kubicki M;Pope HG Jr;Kaufman MJ
最近的研究长期同化雄激素（AAS）用户报告杏仁核结构和功能连接异常。我们评估了杏仁核网络的主要联合束--额枕束（IFOF）的白色物质微结构。扩散加权图像采集自9名男性长期AAS用户和8名年龄在36-51岁之间的匹配对照组，使用标准化管道（基于区域的空间统计）进行处理。组间差异采用线性回归进行检查，并对年龄和当前睾酮水平进行调整。与非使用者相比，AAS使用者在IFOF中表现出显著更高的各向异性分数（FA）。在左侧IFOF上，使用者的FA明显高于非使用者，但在右侧IFOF上只有适度的、不显著的差异。此外，FA与终生累积AAS剂量呈正相关。我们的研究结果表明，长期使用AAS改变IFOF白色物质的组织和完整性，这反过来可能会影响杏仁核相关的过程，如奖励系统功能。因此，需要进一步的研究来复制更大的受试者组的结果，以确定FA异常的功能意义。
Recent studies of long-term anabolic-androgenic steroid (AAS) users reported amygdala structural and functional connectivity abnormalities. We assessed white matter microstructure in the inferior-fronto-occipital fasciculus (IFOF), a major associative bundle of the amygdala network. Diffusion weighted images acquired from 9 male long-term AAS users and 8 matched controls aged 36-51 years old were processed using a standardized pipeline (Tract-Based Spatial Statistics). Group differences were examined using linear regression with adjustment for age and current testosterone level. Compared to nonusers, AAS users exhibited significantly higher fractional anisotropy (FA) in the IFOF. Users showed markedly greater FA than nonusers on the left IFOF but only a modest, nonsignificant difference on the right IFOF. Moreover, FA was positively associated with lifetime cumulative AAS dose. Our results suggest that long-term AAS use alters IFOF white matter organization and integrity, which in turn might affect amygdala-related processes such as reward system function. Accordingly, further studies are needed to replicate findings in larger subject groups to determine the functional significance of the FA abnormality.