TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling
TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling
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DOI：
10.1016/s0014-5793(98)00135-5
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发表时间：
1998-03-06
期刊：
影响因子：
3.5
通讯作者：
Dixit, VM
中科院分区：
文献类型：
--
作者：
Pan, GH;Ni, J;Dixit, VM
TRAIL/Apo-2L诱导多种肿瘤细胞系的快速凋亡。肿瘤坏死因子受体相关分子家族已被鉴定为TRAIL的受体。在此，我们报告了TRAIL受体家族的另一个成员TRUNDD（具有截短死亡结构域的TRAIL受体）的鉴定。在多种人体组织中检测到TRUNDD转录物。TRUNDD与所有已知的TRAIL受体高度同源，并且具有细胞外TRAIL结合结构域，但缺乏功能性细胞内死亡结构域，并且不诱导细胞凋亡。与抑制作用一致，TRUNDD的异位表达减弱了哺乳动物细胞中TRAIL诱导的细胞凋亡。(C)1998年欧洲生物化学学会联合会。
TRAIL/Apo-2L induces rapid apoptosis of a variety of tumor cell lines. A family of tumor necrosis factor receptor-related molecules have been identified as receptors for TRAIL. Herein, we report the identification of another member of the TRAIL receptor family, TRUNDD (TRAIL receptor with a truncated death domain). The TRUNDD transcript was detected in multiple human tissues. TRUNDD is highly homologous to all known TRAIL receptors and has an extracellular TRAIL-binding domain but lacks a functional intracellular death domain and does not induce apoptosis. Consistent with an inhibitory role, ectopic expression of TRUNDD attenuated TRAIL-induced apoptosis in mammalian cells. (C) 1998 Federation of European Biochemical Societies.