Male Partners of Infertile Couples with Seminal Infections of Human Papillomavirus Have Impaired Fertility Parameters
Male Partners of Infertile Couples with Seminal Infections of Human Papillomavirus Have Impaired Fertility Parameters
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DOI：
10.1155/2017/4684629
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发表时间：
2017-01-01
影响因子：
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通讯作者：
Consolaro, Marcia E. L.
中科院分区：
文献类型：
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作者：
Damke, Edilson;Kurscheidt, Fabio A.;Consolaro, Marcia E. L.
有几项研究探讨了病毒感染对男性不育的影响。然而，目前尚不清楚人类乳头瘤病毒(HPV)是否能改变精液参数。这项研究的目的是确定寻求生育评估的夫妇的男性伴侣精液中HPV的患病率。此外，我们评估了HPV感染影响精液参数的可能性。2015年10月至2016年3月期间，巴西马林加圣卡米洛实验室精子分析科共收集了229份精液样本。分析精液基本参数，聚合酶链式反应检测HPV并进行基因分型。HPVDNA的阳性率为16.6%。其中，10.5%为单型HPV感染，6.1%为多重HPV感染，5.7%为单纯高危型HPV感染，6.1%为单纯低危型HPV感染。单型和多型HPV阳性与粘度异常有关，多型HPV阳性也与精子减少、pH升高和白细胞增多有关。这些发现表明，患有精液HPV感染的不育夫妇的男性伴侣可能患有前列腺腺功能障碍，这可能会影响生育。
Several studies have addressed the impact of viral infections on male infertility. However, it is still unknown whether human papillomavirus (HPV) can alter seminal parameters. The aim of this study was to determine the prevalence of HPV in the semen of male partners of couples seeking fertility evaluation. Additionally, we assessed the possibility that HPV infections affect seminal parameters. A total of 229 semen samples were collected from men in the Sperm Analysis Section of Sao Camilo Laboratory of Maringa, Brazil, between October 2015 and March 2016. Basic seminal parameters were analyzed, and HPV was detected and genotyped by polymerase chain reaction. HPV DNA was detected in 16.6% of samples. Of these, 10.5% had single type HPV infections, 6.1% had multiple HPV infections, 5.7% had exclusively high-risk HPV, and 6.1% had exclusively low-risk HPV. Samples positive for single and multiple types of HPV were associated with abnormal viscosity, and samples positive for multiple HPV types were also associated with hypospermia, higher pH, and increased leukocyte numbers. These findings suggest that the male partners of infertile couples with seminal HPV infections may have prostate disturbances indicative of glandular dysfunction, which may influence fertility.