Multimethod assessment of pubertal timing and associations with internalizing psychopathology in early adolescent girls.
Multimethod assessment of pubertal timing and associations with internalizing psychopathology in early adolescent girls.
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DOI：
10.1037/abn0000721
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发表时间：
2022-01
期刊：
影响因子：
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通讯作者：
Pfeifer, Jennifer H
中科院分区：
文献类型：
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作者：
Barendse, Marjolein E A;Byrne, Michelle L;Flournoy, John C;McNeilly, Elizabeth A;Guazzelli Williamson, Victoria;Barrett, Ann-Marie Y;Chavez, Samantha J;Shirtcliff, Elizabeth A;Allen, Nicholas B;Pfeifer, Jennifer H
青春期提前一直与青春期女孩的内化精神病理学有关。在这里，我们的目的是检查时间和心理健康结果之间的关联是否因青春期时间和内化精神病理学的测量而变化，肾上腺和性腺过程之间是否存在差异，以及同时或未来更强。我们对 174 名女性青少年（时间 1 年龄为 10.0-13.0）进行了两次评估，间隔 18 个月。参与者提供了对抑郁/焦虑症状和青春期发育、主观青春期时间和初潮日期的自我报告评估。他们的父母/监护人还报告了青少年的青春期发育和主观青春期时间。我们评估了唾液 DHEA、睾酮和雌二醇水平，并进行了临床访谈以确定是否存在病例水平的内化障碍。根据这些数据，我们计算了两个时间点的 11 项青春期计时指标，以及 7 项内化精神病理学指标，并将这些指标输入规范曲线分析中。总体而言，青春期提前与内化精神病理学的增加有关。前瞻性关联比同时关联更强，这表明青春期早期过程的时间可能对于以后患精神疾病的风险尤其重要。当青春期时间基于 Tanner 阶段线图且结果为病例级 DSM-IV 抑郁症或 HiTOP 痛苦障碍时，关联最强。基于激素水平的时间与内化精神病理学无关，这表明通过可见身体特征的时间测量捕获的心理社会机制可能是青春期女孩中内化精神病理学比生物机制更有意义的决定因素。未来的研究应该精确地研究这些心理社会机制。青春期提前是青春期焦虑和抑郁发展的危险因素。本文的研究结果表明，这种联系取决于青春期时间的测量方式，并且青春期早期过程的时间可能对于青春期女孩以后患精神疾病的风险尤其重要。它表明，通过对可见身体特征的时间测量来捕获的心理社会机制可能比荷尔蒙机制更有意义地预测抑郁和焦虑。
Early pubertal timing has consistently been associated with internalizing psychopathology in adolescent girls. Here, we aimed to examine whether the association between timing and mental health outcomes varies by measurement of pubertal timing and internalizing psychopathology, differs between adrenarcheal and gonadarcheal processes, and is stronger concurrently or prospectively. We assessed 174 female adolescents (age 10.0-13.0 at Time 1) twice, with an 18-month interval. Participants provided self-reported assessments of depression/anxiety symptoms and pubertal development, subjective pubertal timing, and date of menarche. Their parents/guardians also reported on the adolescent’s pubertal development and subjective pubertal timing. We assessed salivary DHEA, testosterone and estradiol levels, and conducted clinical interviews to determine the presence of case level internalizing disorders. From these data, we computed 11 measures of pubertal timing at both time points, as well as 7 measures of internalizing psychopathology, and entered these in a Specification Curve Analysis. Overall, earlier pubertal timing was associated with increased internalizing psychopathology. Associations were stronger prospectively than concurrently, suggesting that timing of early pubertal processes might be especially important for later risk of mental illness. Associations were strongest when pubertal timing was based on the Tanner Stage Line Drawings and when the outcome was case-level DSM-IV depression or HiTOP distress disorders. Timing based on hormone levels was not associated with internalizing psychopathology, suggesting that psychosocial mechanisms, captured by timing measures of visible physical characteristics, might be more meaningful determinants of internalizing psychopathology than biological ones in adolescent girls. Future research should precisely examine these psychosocial mechanisms. Early pubertal timing is a risk factor for the development of anxiety and depression in adolescence. The findings of this paper show that this link depends on how pubertal timing is measured and that timing of early pubertal processes might be especially important for later risk of mental illness in adolescent girls. It suggests that psychosocial mechanisms, captured by timing measures of visible physical characteristics, might be more meaningful predictors of depression and anxiety than hormonal ones.