Beta S gene in Sicily is in linkage disequilibrium with the Benin haplotype: implications for gene flow.
Beta S gene in Sicily is in linkage disequilibrium with the Benin haplotype: implications for gene flow.
复制标题
西西里岛的 Beta S 基因与贝宁单倍型连锁不平衡：对基因流的影响。
DOI：
10.1002/ajh.2830270214
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发表时间：
1988
影响因子：
12.8
通讯作者：
Labie,D
中科院分区：
文献类型：
--
作者：
Ragusa,A;Lombardo,M;Sortino,G;Lombardo,T;Nagel,RL;Labie,D
Hemoglobin β‐like gene cluster haplotypes defined by restriction enzyme polymorphic sites are useful in determining the origin of the βSgene found in several human populations. We present here evidence that the βSgene found among Sicilians is associated with the same haplotype observed among sickle cell anemia patients from Central West Africa. In addition, this haplotype is either nonexistent or very rare among normal Sicilian individuals. We conclude that the βSgene was introduced to Sicily from North Africa and that the gene flow originated in Central West Africa and traveled north through historically well‐defined trans‐Saharan commercial routes.
