Factors influencing increases in CD4 cell counts of HIV-positive persons receiving long-term highly active antiretroviral therapy
Factors influencing increases in CD4 cell counts of HIV-positive persons receiving long-term highly active antiretroviral therapy
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DOI：
10.1086/425075
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发表时间：
2004-11-15
影响因子：
6.4
通讯作者：
Phillips, AN
中科院分区：
文献类型：
--
作者：
Smith, CJ;Sabin, CA;Phillips, AN
背景高效抗逆转录病毒治疗（HAART）可改善免疫功能。我们试图研究与人类免疫缺陷病毒（HIV）阳性的抗逆转录病毒初治患者开始HAART时CD 4细胞计数增加相关的因素。对596名受试者进行了中位2.5年的随访（四分位距，1.0-4.0年）。分析HAART治疗前3个月及治疗后3个月CD 4细胞计数变化的相关因素。在HAART治疗6、12和24个月后，CD 4细胞计数的中位数分别增加了114、181和248个细胞/mm 3; 84%、84%和80%的受试者的病毒载量分别为
Background. Highly active antiretroviral therapy (HAART) results in an improvement in immunologic function. We sought to investigate the factors associated with increases in CD4 cell count among human immunodeficiency virus (HIV)-positive antiretroviral-naive patients starting HAART.Methods. Five hundred ninety-six subjects were followed for a median of 2.5 years (interquartile range, 1.0-4.0 years). Factors associated with changes in CD4 cell counts in the first 3 months of HAART and from 3 months onwards were analyzed.Results. After 6, 12, and 24 months of HAART, the median increases in CD4 cell counts were 114, 181, and 248 cells/mm(3), respectively; 84%, 84%, and 80% of subjects had a virus load of