Osteoimmunomodulation for the development of advanced bone biomaterials
Osteoimmunomodulation for the development of advanced bone biomaterials
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DOI：
10.1016/j.mattod.2015.11.004
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发表时间：
2016-07-01
期刊：
影响因子：
24.2
通讯作者：
Xiao, Yin
中科院分区：
文献类型：
--
作者：
Chen, Zetao;Klein, Travis;Xiao, Yin
成骨细胞作为成骨的直接效应细胞，常用于评价骨生物材料的体外成骨能力，传统的骨生物材料开发的生物学原理是直接刺激成骨分化。基于这一原则，目前大部分的努力都花在优化生物力学和物理化学特性上，以诱导间充质干细胞向成骨分化。这种策略在骨生物材料的开发中取得了一定的成功;然而，体外和体内研究之间的不一致并不罕见，这意味着管理材料介导成骨能力的机制尚未得到很好的理解。骨免疫学揭示了免疫细胞在调节骨动力学中的重要作用。忽视免疫应答的重要性是传统策略的主要缺点，并且可以解释体外和体内条件之间的不一致。在这里，我们提出了骨免疫调节（OIM）在生物材料介导的成骨过程中的免疫反应的重要性认识。因此，我们提出了骨生物材料向骨免疫调节材料的范式转变，并讨论了骨生物材料骨免疫调节性能的评价策略。作者的目标是，这篇综述将改变传统的骨生物材料评估方法，并有助于开发具有骨免疫调节特性的新型骨生物材料，用于骨科和牙科应用。
As direct effector cells for osteogenesis, osteoblastic cells are commonly used for evaluating the in vitro osteogenic capacity of bone biomaterials, and the traditional biological principle for developing bone biomaterials is to directly stimulate osteogenic differentiation. With this principle, most efforts are currently spent on optimizing the bio-mechanical and physicochemical properties to induce osteogenic differentiation of mesenchymal stem cells. This strategy has achieved certain success in the development of bone biomaterials; however, inconsistencies between in vitro and in vivo studies are not uncommon, implying the mechanisms that govern the material's capacity to mediate osteogenesis is not well-understood. Osteoimmunology has revealed the vital role of immune cells in regulating bone dynamics. Neglecting the importance of the immune response is a major shortcoming of the traditional strategy, and may explain inconsistencies between in vitro and in vivo conditions. Here, we proposed osteoimmunomodulation (OIM) in recognition of the importance of the immune response during biomaterial-mediated osteogenesis. Accordingly, we proposed the paradigm shift of bone biomaterials to an osteoimmunomodulatory material and discussed the evaluation strategy for the osteoimmunomodulation property of bone biomaterials. It is the ambition of authors that this review will change traditional methods for bone biomaterials assessment and assist in developing new bone biomaterials with the osteoimmunomodulatory property for orthopedic and dental applications.