Measurement of fractional anisotropy using diffusion tensor MRI in supratentorial astrocytic tumors
Measurement of fractional anisotropy using diffusion tensor MRI in supratentorial astrocytic tumors
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DOI：
10.1023/a:1023977520909
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发表时间：
2003-06-01
影响因子：
3.9
通讯作者：
Kabasawa, H
中科院分区：
文献类型：
--
作者：
Beppu, T;Inoue, T;Kabasawa, H
在体内，由于组织中存在复杂的微结构屏障，水的扩散表现出方向性。水扩散的方向性程度可以用扩散张量磁共振成像(DTI)的分数各向异性(FA)值来表示。本研究的目的是确定FA值是否反映了星形细胞肿瘤的微结构。我们对31例星形细胞肿瘤患者进行了DTI检查，并在CT引导下立体定向活检前测量了肿瘤和正常脑区的FA值。活检后，比较FA值以评估肿瘤组织的细胞密度和血管密度。尽管不同组织学类型的平均FA值有不同的趋势，但所有肿瘤的平均FA值都低于正常脑区。FA值与细胞密度呈正相关(r=0.65，p
In vivo, water diffusion displays directionality due to presence of complex microstructural barriers in tissue. The extent of directionality of water diffusion can be expressed as a fractional anisotropy (FA) value, using diffusion tensor MR imaging (DTI). The aim of this study was to determine whether FA values indicate microstructures in astrocytic tumors. We performed DTI in 31 patients with astrocytic tumor, and measured the FA values of tumor and normal brain regions prior to CT-guided stereotactic biopsy. After biopsy, FA values were compared to assess the cellularity and vascularity of tumor tissue. Although mean FA values trended to differ among histological types, all mean tumor FA values were lower than those of normal brain regions. Positive correlation was observed between FA values and both cellularity (r=0.65, p