Local cerebral glucose utilization in epileptic seizures of the mutant El mouse
Local cerebral glucose utilization in epileptic seizures of the mutant El mouse
复制标题
突变型 El 小鼠癫痫发作时的局部脑葡萄糖利用
DOI：
10.1016/0006-8993(83)90670-4
复制
发表时间：
1983
期刊：
影响因子：
2.9
通讯作者：
Yoshihiro Shinkawa
中科院分区：
文献类型：
--
作者：
J. Suzuki;Y. Nakamoto;Yoshihiro Shinkawa
用[14C]2-脱氧葡萄糖技术研究突变E1小鼠癫痫发作的神经通路和病灶。在强直阵挛发作的小鼠中，整个新皮质和海马体的代谢率显著增加。相比之下，丘脑核、中央灰核、蓝斑核和一些间质核的代谢率明显较低。E1小鼠的癫痫病灶可能存在于海马体中。
The neural pathway and the focus of the epileptic seizure of mutant E1 mice were studied by the [14C]2-deoxyglucose technique. In the mice with full tonic-clonic seizure, the entire neocortex and hippocampus showed a remarkably increased metabolic rate. By contrast, a lower metabolic rate was evident in the thalamic nuclei, central gray, locus coeruleus and some interstitial nuclei. The epileptic focus in E1 mice presumably exist in the hippocampus .