Improving the hyperpolarization of (31)P nuclei by synthetic design.
Improving the hyperpolarization of (31)P nuclei by synthetic design.
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通过合成设计改善（31）P核的超极化。
DOI：
10.1021/acs.jpcb.5b00686
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发表时间：
2015-04-16
影响因子：
3.3
通讯作者：
Duckett, Simon B.
中科院分区：
文献类型：
--
作者：
Burns, Michael J.;Rayner, Peter J.;Green, Gary G. R.;Highton, Louise A. R.;Mewis, Ryan E.;Duckett, Simon B.
传统的31P NMR或MRI测量相对于1H检测灵敏度低，因此需要更长的扫描时间。我们在这里表明，通过与对氢的可逆相互作用，31P核的超极化可以在一系列含有杂芳基序的区域异构体膦酸酯中传递大量的信号增强，这些区域异构体膦酸酯是为了确定极化转移的最佳分子支架而合成的。部分氘化吡啶取代膦酸酯的31P信号增强3588倍（极化率为2.34%）。当分析物浓度为10 mM时，这种超极化水平足以允许在9.4 T观察场下在秒内记录单次扫描31P的幻影MR图像，其信噪比高达94.4。相比之下，在标准条件下12小时2048的扫描测量产生的信噪比仅为11.4。3p超偏振图像也报道了来自7 T临床前扫描仪。
Traditional 31P NMR or MRI measurements suffer from low sensitivity relative to 1H detection and consequently require longer scan times. We show here that hyperpolarization of 31P nuclei through reversible interactions with parahydrogen can deliver substantial signal enhancements in a range of regioisomeric phosphonate esters containing a heteroaromatic motif which were synthesized in order to identify the optimum molecular scaffold for polarization transfer. A 3588-fold 31P signal enhancement (2.34% polarization) was returned for a partially deuterated pyridyl substituted phosphonate ester. This hyperpolarization level is sufficient to allow single scan 31P MR images of a phantom to be recorded at a 9.4 T observation field in seconds that have signal-to-noise ratios of up to 94.4 when the analyte concentration is 10 mM. In contrast, a 12 h 2048 scan measurement under standard conditions yields a signal-to-noise ratio of just 11.4. 31P-hyperpolarized images are also reported from a 7 T preclinical scanner.
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影响因子：
4.6
作者：
Fekete M;Bayfield OW;Duckett SB;Hart S;Mewis RE;Pridmore N;Rayner PJ;Whitwood A
通讯作者：
Whitwood A
影响因子：
4.9
作者：
Aguilar, Juan A.;Elliott, Paul I. P.;Duckett, Simon B.
通讯作者：
Duckett, Simon B.
影响因子：
5.8
作者：
De Clercq, E.
通讯作者：
De Clercq, E.
影响因子：
4.6
作者：
Allen, Kevin J. H.;Nicholls-Allison, Emma C.;Twamley, Brendan
通讯作者：
Twamley, Brendan
影响因子：
4.4
作者：
Feng, Yesu;Theis, Thomas;Warren, Warren S.
通讯作者：
Warren, Warren S.