Mathematics of cell motility: have we got its number?
Mathematics of cell motility: have we got its number?
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DOI：
10.1007/s00285-008-0182-2
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发表时间：
2009-01-01
影响因子：
1.9
通讯作者：
Mogilner, Alex
中科院分区：
文献类型：
--
作者：
Mogilner, Alex
数学和计算建模正迅速成为一种重要的研究技术，补充了传统的实验生物学方法。然而，缺乏标准的建模方法，难以将生物现象转化为数学语言，以及生物和数学思维的差异继续阻碍科学进步。在这里，我们专注于一个领域的细胞运动的特点是一个异常高的建模活动，主要是由于大量的定量，生物物理数据，“模块化”的运动特性，以及该地区的实验领导者开拓性的视野。在这篇综述中，在简要介绍细胞运动生物学之后，我们讨论了肌动蛋白动力学、突出、粘附、收缩以及细胞形状和运动的定量模型，这些模型对生物学发现过程产生了影响。我们还评论建模方法和开放的问题。
Mathematical and computational modeling is rapidly becoming an essential research technique complementing traditional experimental biological methods. However, lack of standard modeling methods, difficulties of translating biological phenomena into mathematical language, and differences in biological and mathematical mentalities continue to hinder the scientific progress. Here we focus on one area-cell motility-characterized by an unusually high modeling activity, largely due to a vast amount of quantitative, biophysical data, 'modular' character of motility, and pioneering vision of the area's experimental leaders. In this review, after brief introduction to biology of cell movements, we discuss quantitative models of actin dynamics, protrusion, adhesion, contraction, and cell shape and movement that made an impact on the process of biological discovery. We also comment on modeling approaches and open questions.