FACILITATION OF LIN-12-MEDIATED SIGNALING BY SEL-12, A CAENORHABDITIS-ELEGANS S182 ALZHEIMERS-DISEASE GENE
FACILITATION OF LIN-12-MEDIATED SIGNALING BY SEL-12, A CAENORHABDITIS-ELEGANS S182 ALZHEIMERS-DISEASE GENE
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DOI：
10.1038/377351a0
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发表时间：
1995-09-28
期刊：
影响因子：
64.8
通讯作者：
GREENWALD, I
中科院分区：
文献类型：
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作者：
LEVITAN, D;GREENWALD, I
秀丽隐杆线虫的lin-1,2和glp-1基因是lin-1,2/Notch受体家族的成员，该家族用于指定细胞命运的细胞间信号（1，2）。通过筛选lin-12功能获得性突变的抑制因子，我们发现了一个新的基因sel-12，它似乎在接受细胞中起作用，以促进lin-12和glp-1介导的信号传导。sel-12基因编码一种具有多个跨膜结构域的蛋白质，与S182相似，S182与早发性家族性阿尔茨海默病有关（3）。高度的序列保守性表明SEL-12和S182蛋白的功能也可能是保守的。
THE lin-12 and glp-1 genes of Caenorhabditis elegans are members of the lin-12/Notch family of receptors for intercellular signals that specify cell fate(1,2). By screening for suppressors of a lin-12 gain-of-function mutation, we identified a new gene, sel-12, which appears to function in receiving cells to facilitate signalling mediated by lin-12 and glp-1. The sel-12 gene encodes a protein with multiple transmembrane domains, and is similar to S182, which has been implicated in early-onset familial Alzheimer's disease(3). The high degree of sequence conservation suggests that the function of the SEL-12 and S182 proteins may also be conserved.