MIRD pamphlet No. 17: the dosimetry of nonuniform activity distributions--radionuclide S values at the voxel level. Medical Internal Radiation Dose Committee.
MIRD pamphlet No. 17: the dosimetry of nonuniform activity distributions--radionuclide S values at the voxel level. Medical Internal Radiation Dose Committee.
复制标题
DOI：
--
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Wesley E. Bolch;L. Bouchet;James S. Robertson;Barry W. Wessels;Jeffry A. Siegel;R. W. Howell;A. Erdi;Bulent Aydogan;S. Costes;Evelyn E. Watson;Aaron B. Brill;Charkes Nd;Darrell R. Fisher;Marguerite T. Hays;Thomas
中科院分区：
文献类型：
--
作者：
Wesley E. Bolch;L. Bouchet;James S. Robertson;Barry W. Wessels;Jeffry A. Siegel;R. W. Howell;A. Erdi;Bulent Aydogan;S. Costes;Evelyn E. Watson;Aaron B. Brill;Charkes Nd;Darrell R. Fisher;Marguerite T. Hays;Thomas
体内放射性核素分布的定量三维体内数据的可用性使得有可能计算身体器官和组织中辐射吸收剂量的相应非均匀分布。这本小册子强调了通过使用体素水平上定义的放射性核素S值，MIRD方案在此类计算中的实用性。剂量点核和蒙特卡罗模拟方法的使用也进行了讨论。PET和SPECT成像可以提供边缘上几毫米的体素中的定量活动数据。对于较小的体素尺寸，使用目前的成像技术无法获得准确的数据。对于亚毫米尺寸，当通过活检或尸检获得组织时，可使用放射自显影方法。本小册子的附录提供了边长为3 mm和6 mm的立方体体素内五种放射性核素的样本S值表。这些S值可用于构建治疗和诊断核医学中遇到的放射性不均匀分布的三维剂量分布。数据也制成表格，用于放射自显影的0.1毫米体素的131 I。两个例子说明了使用体素S值，其次是使用三维剂量分布的理解和预测生物反应的讨论。
The availability of quantitative three-dimensional in vivo data on radionuclide distributions within the body makes it possible to calculate the corresponding nonuniform distribution of radiation absorbed dose in body organs and tissues. This pamphlet emphasizes the utility of the MIRD schema for such calculations through the use of radionuclide S values defined at the voxel level. The use of both dose point-kernels and Monte Carlo simulation methods is also discussed. PET and SPECT imaging can provide quantitative activity data in voxels of several millimeters on edge. For smaller voxel sizes, accurate data cannot be obtained using present imaging technology. For submillimeter dimensions, autoradiographic methods may be used when tissues are obtained through biopsy or autopsy. Sample S value tabulations for five radionuclides within cubical voxels of 3 mm and 6 mm on edge are given in the appendices to this pamphlet. These S values may be used to construct three-dimensional dose profiles for nonuniform distributions of radioactivity encountered in therapeutic and diagnostic nuclear medicine. Data are also tabulated for 131I in 0.1-mm voxels for use in autoradiography. Two examples illustrating the use of voxel S values are given, followed by a discussion of the use of three-dimensional dose distributions in understanding and predicting biologic response.