Plasma Endothelin‐1 Levels in Human Lung Transplant Recipients
Plasma Endothelin‐1 Levels in Human Lung Transplant Recipients
复制标题
人肺移植受者的血浆内皮素-1 水平
DOI：
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发表时间：
1995
影响因子：
3
通讯作者：
A. Giaid
中科院分区：
文献类型：
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作者：
H. Shennib;C. Serrick;D. Saleh;Alexander Reis;D. Stewart;A. Giaid
摘要：内皮素-1（ET-1）是由血管内皮细胞产生的一种强有力的缩血管肽，被认为在肺血管的病理生理学中起重要作用。我们研究了肺移植受者在隔离肺移植前后不同时间血浆ET-1水平的早期变化。移植前血浆ET-1水平为0.8 ± 0.1pg/ml。在同种异体移植物开放和血管再灌注后不久，其显著增加至2.6 ± 0.5 pg/ml，并在移植后4 h（2.3 ± 0.5 pg/ml）、6 h（2.4 ± 0.6 pg/ml）和12 h（1.7 ± 0.3 pg/ml）保持较高水平。移植后24 h ET-1水平为1.3 ± 0.3 pg/ml，1周为0.9 ± 0.3 pg/ml。ET-1血浆水平的这种早期升高与我们观察到的移植后早期肺血管阻力、肺动脉压和心输出量的变化一致。这些研究结果表明，肺移植后不久血浆ET-1水平的增加可能有一个不利的影响，在术后过程中移植后早期。
Summary: Endothelin-1 (ET-1) is a potent vasoconstrictor peptide produced by vascular endothelial cells and is believed to play an important role in the pathophysiology of the pulmonary vasculature. We have investigated the early changes in ET-1 plasma levels in lung transplant recipients at various intervals before and after isolated lung transplantation. The mean plasma ET-1 level immediately before transplantation was 0.8 ± 0.1 pg/ml. This was significantly increased to 2.6 ± 0.5 pg/ml shortly after unclamping and vascular reperfusion of the allograft, and remained high 4 h (2.3 ± 0.5 pg/ml), 6 h (2.4 ± 0.6 pg/ml), and 12 h (1.7 ± 0.3 pg/ml) after transplantation. Thereafter, the level of ET-1 started to decline, reaching 1.3 ± 0.3 pg/ml 24 h and 0.9 ± 0.3 pg/ml 1 week after transplantation. This early increase in ET-1 plasma level is consistent with our observation of alterations in pulmonary vascular resistance, pulmonary artery pressure and cardiac output early after transplantation. These findings demonstrate that an increase in plasma ET-1 levels shortly after lung transplantation may have a detrimental effect during the postoperative course early after transplantation.