Autonomic dysfunction in men with Parkinson's disease.
Autonomic dysfunction in men with Parkinson's disease.
复制标题
帕金森病男性的自主神经功能障碍。
DOI：
10.1159/000116810
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发表时间：
1992
影响因子：
2.4
通讯作者：
Sanchez-Ramos,JR
中科院分区：
文献类型：
--
作者：
Singer,C;Weiner,WJ;Sanchez-Ramos,JR
48名男性帕金森病（PD）进行了采访，利用问卷评估自主神经功能。研究人群包括PD患者（平均年龄：65.8岁，PD平均持续时间：8年）和32名老年健康非帕金森男性（平均年龄：70.4岁）。我们发现帕金森病患者中以下自主神经功能障碍症状的患病率显著较高：勃起功能障碍（60.4 vs. 37.5%），膀胱排空不全感（41.6 vs. 15.6%）、尿急（45.8 vs. 3.125%）、便秘（43.9 vs. 6.25%）、吞咽困难（22.9 vs. 6.25%）和直立性头晕（21.95 vs. 0%）。89%的帕金森病患者至少有一种自主神经症状，而对照组只有43%（p < 0.05）。这项研究是第一次全面调查的自主神经系统疾病在PD相比，老年健康对照，并证实自主神经系统功能障碍是一个普遍的问题，在PD。勃起功能障碍是这一患者群体的一个重要问题，并导致生活质量下降。
Forty-eight men with Parkinson’s disease (PD) were interviewed utilizing a questionnaire which evaluated autonomic function. The study population included PD patients (mean age: 65.8 years, mean duration of PD: 8 years) and 32 elderly healthy nonparkinsonian males (mean age: 70.4 years). We found a significantly higher prevalence of the following symptoms of autonomic dysfunction in the parkinsonian patients: erectile dysfunction (60.4 vs. 37.5%), sensation of incomplete bladder emptying (41.6 vs. 15.6%), urgency (45.8 vs. 3.125%), constipation (43.9 vs. 6.25%), dysphagia (22.9 vs. 6.25%) and orthostatic dizziness (21.95 vs. 0%). Eighty-nine percent of parkinsonian patients had at least one of these autonomic symptoms, compared to 43% of control subjects (p < 0.05). This study is the first comprehensive survey of autonomic symptomatology in PD compared to elderly healthy controls and confirms that autonomic nervous system dysfunction is a pervasive problem in PD. Erectile dysfunction is a significant problem in this patient group and contributes to deterioration in the quality of life.