Is radiographic lumbar spondylolisthesis associated with occupational exposures? Findings from a nested case control study within the Wakayama spine study
Is radiographic lumbar spondylolisthesis associated with occupational exposures? Findings from a nested case control study within the Wakayama spine study
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DOI：
10.1186/s12891-019-2994-1
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发表时间：
2019-12-26
影响因子：
2.3
通讯作者：
Walker-Bone, Karen
中科院分区：
文献类型：
--
作者：
Ishimoto, Yuyu;Cooper, Cyrus;Walker-Bone, Karen
背景资料：探讨影像学腰椎滑脱与职业因素之间的关系，在和歌山脊柱研究（WSS）中进行病例对照研究。方法：WSS是一项在日本成年人中进行的横断面观察性研究。所有参与者都完成了一生的职业史，并根据预先定义的协议进行了腰椎（L1-S1）的X射线检查。一名经过培训的外科医生根据一个或多个节段的前滑脱或后滑脱≥ 5%对脊椎滑脱的存在进行分级。例，腰椎滑脱症，与对照组相比，没有，他们的主要职业和职业exposs.Results：在总数，数据可用于722名成年人（245名男性和477名女性），平均年龄70.1（范围53-93）岁。根据预先定义的影像学标准，117例被定义为脊椎前移（例），留下605例对照。病例组与对照组在年龄、性别、BMI、吸烟或饮酒方面无显著差异。然而，在调整年龄、性别和BMI后，报告职业驾驶>= 4小时/天的病例可能性是报告职业驾驶>= 4小时/天的病例的两倍多（OR 2.39，95%CI 1.08-5.27）。此外，在以75岁为分界点按年龄分层后，在年龄< 75岁的人群中，报告曾在农业/渔业工作的病例可能性高出3倍以上（OR 3.47，95% CI 1.29-9.29）。降低风险的情况下，与爬坡/步骤和walking.Conclusions：职业驾驶和在农业/渔业工作的历史与放射性脊椎前移在这个横断面人群研究。这一发现需要在纵向研究中进一步评估。
Background: To explore the relationship between radiographic spondylolisthesis and occupational factors in a case-control study nested within the Wakayama Spine Study (WSS).Methods: The WSS is a cross-sectional observational study amongst Japanese adults. All participants completed a lifetime occupational history and underwent X-rays of the lumbar spine (L1-S1) according to a pre-defined protocol. One trained surgeon graded the presence of a spondylolisthesis based upon >= 5% anterior or posterior slip at one or more levels. Cases, with lumbar spondylolisthesis, were compared with controls without, for their principal occupation and occupational exposures.Results: In total, data were available for 722 adults (245 men and 477 women), mean age 70.1 (range 53-93) years. According to the pre-defined radiographic criteria, 117 were defined with spondylolisthesis (cases), leaving 605 controls. Cases were not significantly different from controls for age, gender, BMI, smoking or alcohol intake. However, cases were more than twice as likely to report occupational driving >= 4 h/day (OR 2.39, 95% CI 1.08-5.27) after adjustment for age, gender and BMI. Additionally, after stratification by age using 75 years as a cut-point, cases were more than 3-fold more likely to report having worked in the agricultural/ fishing industries (OR 3.47, 95% CI 1.29-9.29) among those aged < 75 years. A reduced risk of being a case was associated with climbing slopes/steps and walking.Conclusions: A history of occupational driving and working in the agricultural/fishing industry were associated with radiographic spondylolisthesis in this cross-sectional population study. This finding requires further evaluation in longitudinal studies.