Pharmacological evidence for the role of central alpha 1B-adrenoceptors in the motor activity and spontaneous movement of mice.
Pharmacological evidence for the role of central alpha 1B-adrenoceptors in the motor activity and spontaneous movement of mice.
复制标题
中枢 α1B-肾上腺素受体在小鼠运动活动和自发运动中作用的药理学证据。
DOI：
10.1016/s0028-3908(00)00151-9
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发表时间：
2001
影响因子：
4.7
通讯作者：
Quartermain,D
中科院分区：
文献类型：
--
作者：
Stone,EA;Lin,Y;Itteera,A;Quartermain,D
中枢α 1-去甲肾上腺素能神经传递已被证明是运动活动控制中多巴胺能传递的重要补充，但负责α 1受体亚型的身份尚未确定。在本实验中，通过测量脑室内施用一系列α 1拮抗剂对三种已知受体亚型（1a、1b和1d）的亲和力不同对小鼠响应换笼的主动行为的影响来研究这一点。研究发现，药物阻断大的和小的运动的效力与已发表的克隆1b受体的亲和力高度相关，但与克隆1a或1d受体的亲和力无关。它的结论是，中央α 1B受体是至关重要的参与调解的（或）肾上腺素能的影响，积极的行为，这一发现有影响的基础和临床研究在运动和情绪障碍。
Central alpha 1-noradrenergic neurotransmission has been shown to be an important complement of dopaminergic transmission in the control of motor activity but the identity of the responsible alpha 1 receptor subtype has not yet been identified. This was investigated in the present experiment by measuring the effects of intraventricular administration of a series of alpha 1 antagonists varying in affinities for the three known receptor subtypes — 1a, 1b and 1d — on active behavior in mice in response to a cage change. It was found that the potency of the drugs to block both gross and small movements correlated highly with published affinities for the cloned 1b receptor but not for those of either the cloned 1a or 1d receptors. It is concluded that central alpha 1B receptors are critically involved in the mediation of the (nor)adrenergic influence on active behavior, a finding which has implications for basic and clinical research in both movement and mood disorders.