Comparison of monophasic versus biphasic stimulation in rTMS over premotor cortex: SEP and SPECT studies
Comparison of monophasic versus biphasic stimulation in rTMS over premotor cortex: SEP and SPECT studies
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DOI：
10.1016/j.clinph.2008.07.279
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发表时间：
2008-11-01
影响因子：
4.7
通讯作者：
Kaji, Ryuji
中科院分区：
文献类型：
--
作者：
Hosono, Yuki;Urushihara, Ryo;Kaji, Ryuji
目的：为了优化重复经颅磁刺激（rTMS）的临床应用，我们比较了不同时相rTMS对体感诱发电位（SEP）和局部脑血流（rCBF）的影响方法：在第一个实验中，比较不同的相位（0.2 Hz单相与0.2 Hz双相）。双相I Hz或假手术条件作为对照。第二个实验是使用单相刺激来探索频率（0.2Hz与0.8Hz）的影响。在左侧运动前区皮层上施加阈下TMS 250次。结果：0.2和0.8Hz的单相rTMS均能显著增加N30波幅比值，而双相刺激对N30波幅比值无显著影响。结论：在运动前区，单相rTMS对SEP和rCBF的影响比双相rTMS更显著，单相rTMS对SEP和rCBF的影响比双相rTMS更有临床意义。(C)2008年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有战斗。
Objective: To optimize the clinical uses of repetitive transcranial magnetic stimulation (rTMS), we compared the effects of rTMS on somatosensory-evoked potentials (SEPs) and regional cerebral blood flow (rCBF) using different phases (monophasic vs. biphasic) or frequencies (0.2 Hz vs. 0.8 Hz) of stimulation.Methods: In the first experiment, different phases were compared (0.2 Hz monophasic vs. 0.2 Hz biphasic). Biphasic I Hz or sham condition served as controls. The second experiment was to explore the effect of frequencies (0.2 Hz vs. 0.8 Hz) using the monophasic stimulation. Substhreshold TMS was applied 250 times over the left premotor cortex. Single photon emission computed tomography (SPECT) was performed before and after monophasic 0.2 Hz or biphasic I Hz rTMS.Results: Monophasic rTMS of both 0.2 and 0.8 Hz significantly increased the ratio of N30 amplitudes as compared with sham rTMS, whereas biphasic stimulation showed no significant effects. SPECT showed increased rCBF in motor cortices after monophasic 0.2 Hz rTMS, but not after biphasic I Hz stimulation.Conclusions: Monophasic rTMS exerted more profound effects on SEPs and rCBF than biphasic rTMS over the premotor cortex.Significance: Monophasic rTMS over the premotor cortex could be clinically more useful than biphasic rTMS. (C) 2008 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All Fights reserved.