Age-related Variations of Human Tear Meniscus and Diagnosis of Dry Eye With Fourier-domain Anterior Segment Optical Coherence Tomography
Age-related Variations of Human Tear Meniscus and Diagnosis of Dry Eye With Fourier-domain Anterior Segment Optical Coherence Tomography
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DOI：
10.1097/ico.0b013e3181fb84ea
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发表时间：
2011-05-01
期刊：
影响因子：
2.8
通讯作者：
Jin, Huan
中科院分区：
文献类型：
--
作者：
Qiu, Xiaodi;Gong, Lan;Jin, Huan
目的：使用傅立叶域前段光学相干断层扫描确定人泪液半月板的年龄相关变化方法：对146例干眼症患者和160例健康对照者进行前瞻性、随机、病例对照研究，按年龄分组：A组（0-19岁）、B组（20-39岁）、C组（40-59岁）、D组（> 60岁）。使用FD-ASOCT（RTVue-100）测量泪液半月板高度、泪液半月板深度和泪液半月板横截面积（TMA）;还估计角膜荧光素染色、泪膜破裂时间、Schirmer I试验和干眼问卷调查。干眼症组的平均泪膜高度、深度和TMA值均低于对照组（P < 0.05）。在中国健康人中，泪液半月板值与年龄呈负相关。各组光学相干断层扫描结果的个体内差异较小。FD-ASOCT诊断干眼的准确率约为70%，临床诊断临界点随年龄增长而降低。观察到显着差异，在两组之间的撕裂半月板边界，TMA，和撕裂透明度：FD-ASOCT提供模糊的成像和精确的测量的撕裂半月板，这是与临床检查一致。因此，FD-ASOCT有望成为干眼筛查和诊断的一项有价值的技术。
Purpose: To determine the age-related variations in the human tear meniscus using Fourier-domain anterior segment optical coherence tomography (FD-ASOCT) and evaluate its application in dry eye screening and diagnosis.Methods: One hundred forty-six patients with dry eye and 160 healthy controls were enrolled in this prospective, randomized, case-control study and grouped according to age: group A (0-19 years), group B (20-39 years), group C (40-59 years), and group D (> 60 years). Tear meniscus height, tear meniscus depth, and tear meniscus cross-sectional area (TMA) were measured using FD-ASOCT (RTVue-100); corneal fluorescein staining, tear film breakup time, Schirmer I test, and a dry eye questionnaire were also estimated.Results: Tear meniscus values were significantly correlated with clinical examination results and dry eye syndrome. Mean tear meniscus height, tear meniscus depth, and TMA values of patients with dry eye were significantly lower than those of the controls (P < 0.05). Tear meniscus values were negatively correlated with age in healthy Chinese subjects. Intraindividual variations in optical coherence tomography results were small in each group. Accuracy of dry eye diagnosis by FD-ASOCT was approximately 70%, and the clinical diagnostic critical point became lower with increasing age. Significant differences were observed in the tear meniscus borderline, TMA, and tear transparency between the 2 groups.Conclusions: FD-ASOCT provides blur-free imaging and precise measurement of the tear meniscus, which is consistent with clinical examinations. Therefore, FD-ASOCT is expected to become a valuable technique in dry eye screening and diagnosis.