Bottlebrush Polymers Based on RAFT and the "C1" Polymerization Method: Controlled Synthesis and Application in Anticancer Drug Delivery.
Bottlebrush Polymers Based on RAFT and the "C1" Polymerization Method: Controlled Synthesis and Application in Anticancer Drug Delivery.
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DOI：
10.1021/acsmacrolett.1c00706
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发表时间：
2022-01
影响因子：
5.8
通讯作者：
Meng Wang;Hui Zou;Wenbing Liu;Na Liu;Zongquan Wu
中科院分区：
文献类型：
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作者：
Meng Wang;Hui Zou;Wenbing Liu;Na Liu;Zongquan Wu
在这项工作中，我们报告了一种合成定义明确的瓶刷聚合物的策略。采用可逆加成-断裂链转移(RAFT)聚合法制备了可控相对分子质量的重氮乙酸酯聚苯乙烯大单体(1-PSN)。重氮可耐RAFT聚合条件，并留在PS大单体的链端。大分子单体的末端重氮基在烯丙基PdCl/L催化下聚合，得到每个主链原子上带有侧链的规整的瓶刷聚合物((1-PSN)ms)。同时，以Pd(II)-端基(1-PSN)m为大分子引发剂，通过重氮大单体聚乙二醇酯(2-PEG)的聚合，合成了刷形PS/聚乙二醇型两亲性瓶刷聚合物。得到的两亲性(1-PS30)50-b-(2-PEG)100在水溶液中可以自组装成定义良好的核壳胶束。胶束的流体力学直径约为146 nm，具有良好的生物相容性。这些结果表明该胶束在药物释放方面具有很大的潜力。
In this work, we reported a strategy to synthesize well-defined bottlebrush polymers. Diazoacetate macromonomers of polystyrene (1-PSn) with controlled molecular weights were prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization. The diazo can tolerate the RAFT polymerization conditions and remained on the chain end of the yielded PS macromonomer. The terminal diazo groups of the macromonomer were polymerized by the allyl PdCl/L catalyst to afford well-defined bottlebrush polymers ((1-PSn)ms) carrying a side chain on each backbone atom. Meanwhile, an amphiphilic bottlebrush polymer containing brush-shaped PS and polyethylene glycol (PEG) was synthesized by polymerization of the diazoacetate macromonomer of PEG (2-PEG) using Pd(II)-terminated (1-PSn)m as the macroinitiator. The yielded amphiphilic (1-PS30)50-b-(2-PEG)100 could self assemble into a well-defined core-shell micelle in aqueous solutions. The hydrodynamic diameter of the micelle was ca. 146 nm and had good biocompatibility. These results indicate the micelles have great potential in drug delivery.