Epileptogenesis after cortical photothrombotic brain lesion in rats
Epileptogenesis after cortical photothrombotic brain lesion in rats
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DOI：
10.1016/j.neuroscience.2007.05.047
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发表时间：
2007-08-10
期刊：
影响因子：
3.3
通讯作者：
Pitkanen, A.
中科院分区：
文献类型：
--
作者：
Karhunen, H.;Bezvenyuk, Z.;Pitkanen, A.
We investigated epileptogenesis after cortical photothrombotic stroke induced with Rose Bengal dye in adult Sprague-Dawley rats. To detect spontaneous seizures, video-electroencephalograms were recorded at 2, 4, 6, 8, and 10 months for 7-14 days (24 h/day). At the end, spatial and emotional learning and memory were assessed using the Morris water-maze and fear-conditioning test, respectively, and the brains were processed for histologic analysis. Seizures were detected in 18% of rats that received photothrombosis. The average seizure frequency was 0.39 seizures per recording day and mean seizure duration was 117 s. Over 60% of seizures occurred during the dark hours. Rats with photothrombotic lesions were impaired in the water-maze (P
