Expression of Jagged1 and its association with hepatitis B virus X protein in hepatocellular carcinoma
Expression of Jagged1 and its association with hepatitis B virus X protein in hepatocellular carcinoma
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Jagged1在肝细胞癌中的表达及其与乙型肝炎病毒X蛋白的关系
DOI：
10.1016/j.bbrc.2007.02.130
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发表时间：
2007-05-04
影响因子：
3.1
通讯作者：
Fan, Daiming
中科院分区：
文献类型：
--
作者：
Gao, Juan;Chen, Caiping;Fan, Daiming
Jagged 1是Notch信号通路的配体之一，调控细胞增殖和分化，在多种恶性肿瘤中发挥重要作用。然而，Jagged 1在肝细胞癌（HCC）中的表达及其与B型肝炎病毒X蛋白（HBx）的关系尚不清楚。在本研究中，我们发现Jagged 1在79.2%（42/53）的肝癌组织中高表达（P < 0.05），且其表达与HBx密切相关（rs = 0.522，P < 0.001）。我们的体外研究还表明，肝癌细胞系中HBx表达的改变导致Jagged 1的一致变化。此外，Jagged 1被发现在HCC组织和HBx表达的HCC细胞系中与HBx共定位并直接相互作用。我们的研究结果表明，Jagged 1，这是由HBx调节，可能有助于肝癌的发展。(c)2007爱思唯尔公司All rights reserved.
Jagged1 is one of the ligands of Notch signaling pathway, which controls cellular proliferation and differentiation, and also plays important roles in various malignant tumors. However, the expression of Jagged1 in hepatocellular carcinoma (HCC) has not been elucidated, nor whether it is associated with hepatitis B virus X protein (HBx). In this study, we found that Jagged1 was highly expressed in 79.2% (42/53) of HCC tissues compared with adjacent nontumor liver (P < 0.05), and its expression was found to be closely related with HBx (rs = 0.522, P < 0.001) in HCC tissues. Our in vitro study also showed that alteration of HBx expression in HCC cell lines led to a consistent change of Jagged1. Moreover, Jagged1 was found to co-localize and directly interact with HBx in HCC tissues and HBx expressed HCC cell lines. Our results reveal that Jagged1, which is regulated by HBx, may contribute to the development of HCC. (c) 2007 Elsevier Inc. All rights reserved.