Quantifying the psychomotor activating effects of cocaine in the rat
Quantifying the psychomotor activating effects of cocaine in the rat
复制标题
DOI：
10.1097/fbp.0b013e3281f522a4
复制
发表时间：
2007-07-01
影响因子：
1.6
通讯作者：
Robinson, Terry E.
中科院分区：
文献类型：
--
作者：
Flagel, Shelly B.;Robinson, Terry E.
涉及分析药物的精神激活作用的研究通常使用运动活动作为精神激活的唯一测量。在低剂量下，精神兴奋剂药物通常主要产生运动过度活跃。然而，随着剂量的增加，行为会以复杂的方式发生变化，部分原因是行为逐渐过渡到由越来越多的刻板动作（如重复的头部运动）主导的行为。因此，在某些剂量下，药物作用的增加反映为运动增加，而在其他剂量下则反映为减少，这使得难以解释运动活动的变化。使用自动视频分析系统（Clever Sys.，Inc. Reston，Virginia，USA），我们量化了大鼠对可卡因的精神反应的各种成分，包括自发活动和侧向头部运动，以及这些行为的速度和/或频率。我们报告说，这些措施的组合提供了一个特别敏感的措施，可卡因的psychornotor激活效果，以及如何作为一个结果，重复药物治疗的行为变化。
Studies that involve analysis of the psychomotor activating effects of drugs often use locomotor activity as the sole measure of psychomotor activation. At low doses, psychostimulant drugs typically produce primarily locomotor hyperactivity. As dose is increased, behavior, however, changes in complex ways, in part because of a transition to behavior progressively dominated by more and more stereotyped actions, such as repetitive head movements. Thus, at some doses an increase in a drug effect is reflected by an increase in locomotion and at others by a decrease, making the interpretation of changes in locomotor activity difficult. Using an automated video analysis system (Clever Sys., Inc. Reston, Virginia, USA), we quantified various components of the psychomotor response to cocaine in the rat, including locomotor activity and lateral head movements, as well as the velocity and/or frequency of these behaviors. We report that the combination of these measures provides an especially sensitive measure of the psychornotor activating effects of cocaine, and how behavior changes as a consequence of repeated drug treatment.