Methylprednisolone as an Intervention Following Myocardial Infarction
Methylprednisolone as an Intervention Following Myocardial Infarction
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甲基泼尼松龙作为心肌梗死后的干预措施
DOI：
10.1177/03000605860140s101
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发表时间：
1986
影响因子：
1.6
通讯作者：
M. Busson
中科院分区：
文献类型：
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作者：
M. Busson
：842例在英国医院中心接受类风湿性关节炎治疗的患者，作为氟比洛芬在1，396例各种风湿性疾病患者中的疗效和安全性的长期可变剂量研究的一部分进行了评价。在本文报告的18个月观察期结束时，晨僵、握力、关节尺寸、关节指数和功能能力明显改善（p <0.001），所有亚组的疼痛严重程度降低，包括因既往治疗无效而进入研究的患者。医生和患者的全球评估显示，在这段时间内，年轻和老年患者都有非常显著的改善，其中客观改善不太明显。64%的副作用报告为胃肠道，中枢神经系统副作用（头痛，头晕）占14%。发生率根据是否处方伴随治疗而变化。老年患者的副作用与年轻患者相似。
: Eight hundred and forty-two patients undergoing treatment for rheumatoid arthritis in hospital centres in the United Kingdom were evaluated as part of a long-term, variable dose study of the efficacy and safety of flurbiprofen in 1,396 patients with a variety of rheumatological disorders. Highly significant (p less than 0.001) improvements were evident in morning stiffness, grip strength, joint size, articular index and functional capacity at the end of the 18-month observation period reported here, as was a decrease in pain severity in all sub-groups, including those patients entering the study because of lack of effect of their previous therapy. Global assessments by doctor and patient showed highly significant improvements over this time period for both young and older patients, in whom objective improvements were less striking. Sixty-four per cent of side-effects reported were gastro-intestinal, CNS side-effects (headache, giddiness) accounting for 14%. The incidence varied according to whether or not concomitant therapy was being prescribed. Side-effects in the elderly were similar in nature to those in younger patients.