Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages.
Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages.
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DOI：
10.1371/journal.pone.0009683
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发表时间：
2010-03-12
期刊：
影响因子：
3.7
通讯作者：
Hogaboam CM
中科院分区：
文献类型：
--
作者：
Murray LA;Rosada R;Moreira AP;Joshi A;Kramer MS;Hesson DP;Argentieri RL;Mathai S;Gulati M;Herzog EL;Hogaboam CM
巨噬细胞促进组织重塑，但在组织纤维化过程中几乎没有调节其活性的机制。血清淀粉样蛋白P（SAP）是五聚蛋白家族的成员，通过Fcγ受体发出信号，已知Fcγ受体影响巨噬细胞活化。我们确定，IPF/UIP患者肺中几种交替活化的促纤维化（M2）巨噬细胞相关蛋白的蛋白水平增加，这些患者的单核细胞显示出向M2巨噬细胞表型倾斜。当全身或局部给予肺时，SAP在治疗上抑制已建立的博来霉素诱导的肺纤维化。异常胶原沉积的减少与肺中M2巨噬细胞的减少和IP 10/CXCL 10的增加相关。这些数据突出了巨噬细胞在纤维化肺病中的作用，并证明了SAP对巨噬细胞的治疗作用，其可以扩展到由过度旺盛的促纤维化巨噬细胞应答引起的许多纤维化适应症。
Macrophages promote tissue remodeling but few mechanisms exist to modulate their activity during tissue fibrosis. Serum amyloid P (SAP), a member of the pentraxin family of proteins, signals through Fcγ receptors which are known to affect macrophage activation. We determined that IPF/UIP patients have increased protein levels of several alternatively activated pro-fibrotic (M2) macrophage-associated proteins in the lung and monocytes from these patients show skewing towards an M2 macrophage phenotype. SAP therapeutically inhibits established bleomycin-induced pulmonary fibrosis, when administered systemically or locally to the lungs. The reduction in aberrant collagen deposition was associated with a reduction in M2 macrophages in the lung and increased IP10/CXCL10. These data highlight the role of macrophages in fibrotic lung disease, and demonstrate a therapeutic action of SAP on macrophages which may extend to many fibrotic indications caused by over-exuberant pro-fibrotic macrophage responses.
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DOI：
10.1073/pnas.0706832104
发表时间：
2007-12-04
影响因子：
11.1
作者：
Tiemessen, Machteld M.;Jagger, Ann L.;Taams, Leonie S.
通讯作者：
Taams, Leonie S.
DOI：
10.1164/rccm.200509-1518oc
发表时间：
2006-04-01
影响因子：
24.7
作者：
Prasse, A;Pechkovsky, DV;Zissel, G
通讯作者：
Zissel, G
影响因子：
6
作者：
Jakubzick, C;Choi, ES;Hogaboam, CM
通讯作者：
Hogaboam, CM
影响因子：
15.9
作者：
Phillips, RJ;Burdick, MD;Strieter, RM
通讯作者：
Strieter, RM
DOI：
10.1073/pnas.0608799103
发表时间：
2006-11-28
影响因子：
11.1
作者：
Haudek, Sandra B.;Xia, Ying;Entman, Mark L.
通讯作者：
Entman, Mark L.