Increased Risk for Intracranial Arterial Stenosis in Subjects With Coronary Artery Calcification
Increased Risk for Intracranial Arterial Stenosis in Subjects With Coronary Artery Calcification
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DOI：
10.1161/strokeaha.114.006996
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发表时间：
2015-01-01
期刊：
影响因子：
8.3
通讯作者：
Rhee, Eun-Jung
中科院分区：
文献类型：
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作者：
Oh, Hyung-Geun;Chung, Pil-Wook;Rhee, Eun-Jung
背景和目的：颅内动脉狭窄（ICAS）被认为是亚洲人中风的一个重要原因。冠状动脉钙化（CAC）是亚临床动脉粥样硬化的替代标志物。我们的目的是分析经颅多普勒超声评估的ICAS与韩国中年人群CAC的关系。方法：本研究纳入了来自健康筛查项目的10550名参与者（81.3%男性，平均年龄43岁），在这些参与者中，经颅多普勒超声检查用于检测bbb50 %的颅内狭窄，该检查基于卒中结局和颅内动脉粥样硬化神经影像学试验修改的标准。多探测器计算机断层扫描评估冠状动脉钙评分（CACS）。CAC分级（0,1 -100和bbb100）由caacs定义。结果：有CAC的患者中有ICAS的比例明显高于无CAC的患者(4.4%比2.8%
Background and Purpose-Intracranial arterial stenosis (ICAS) is considered an important cause of stroke in Asians. Coronary artery calcification (CAC) is a surrogate marker for subclinical atherosclerosis. We aimed to analyze the association of ICAS assessed by transcranial Doppler ultrasonography and CAC in middle-aged Korean population.Methods-This study included 10 550 participants (81.3% men, mean age 43 years) from a health screening program, in whom transcranial Doppler ultrasonography was used to detect >50% intracranial stenosis based on criteria modified from the stroke outcomes and neuroimaging of intracranial atherosclerosis trial. Multidetector computed tomography was used to assess coronary artery calcium score (CACS). CAC grade (0, 1-100, and >100) was defined by CACS.Results-The subjects with CAC showed significantly higher proportion of subjects with ICAS compared with those without CAC (4.4% versus 2.8%; P