Chemical characteristics and cytotoxic correlation analysis of PM2.5 in Jinan
Chemical characteristics and cytotoxic correlation analysis of PM2.5 in Jinan
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DOI：
10.1007/s11869-022-01185-0
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发表时间：
2022-04
期刊：
影响因子：
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通讯作者：
Xinli Wang;Min-min Yang;Guirong Wang;Lili Du;Haiyan Li;Yan Wang
中科院分区：
文献类型：
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作者：
Xinli Wang;Min-min Yang;Guirong Wang;Lili Du;Haiyan Li;Yan Wang
大气细颗粒物（PM2.5）对人体健康有重要影响，尤其是引起肺部疾病。无机元素和有机化合物是PM2.5中主要的毒性成分，可导致细胞死亡和组织损伤。为研究PM2. 5及其化学成分的浓度特征和细胞毒性效应，于2016年在济南市采集了PM2. 5样品。分析了PM2.5对人肺上皮细胞（A549）主要无机元素和有机成分的影响，并检测了细胞活力。结果表明，2016年济南市PM2. 5浓度高于全国90%的城市，PM2. 5中无机元素和多环芳烃（PAHs）浓度也高于其他研究。细胞毒性分析表明，随着PM2. 5浓度的增加，细胞活力显著降低，说明PM2. 5污染可引起细胞的不良损伤。大多数无机元素和有机组分如汞、荧蒽、蒽和二苯并（a，h）蒽的浓度与细胞活力呈显著负相关，表明这些物种是有效的化学毒性组分，在PM2. 5引起的不良健康效应中起着关键作用。
Atmospheric fine particulate matter (PM2.5) can exert a significant impact on human health, especially on causing pulmonary diseases. Inorganic elements and organic compounds are primary toxic components in PM2.5that cause cell death and tissue injury. To study the concentration characteristics as well as cytotoxic effects of PM2.5and chemical components, PM2.5samples were collected in Jinan during 2016. Major inorganic elements and organic components were analyzed and the cell viability of human lung epithelial cells (A549) exposed to PM2.5was examined. The results showed that PM2.5concentrations were higher in Jinan than 90% of cities in China during 2016, and the concentrations of inorganic elements and polycyclic aromatic hydrocarbon (PAHs) in PM2.5were also higher than in other studies. Furthermore, the cytotoxic analysis indicated that cell viability decreased significantly in correspondence with the increase of PM2.5concentrations, which indicated that PM2.5pollution could induce adverse cell injury. The concentrations of most inorganic elements and organic components such as mercury, fluoranthene, anthracene, and dibenzo (a,h) anthracene were significantly negatively correlated with cell viability, indicating that these species were effective chemical toxic components and played a key role in adverse health effects induced by PM2.5.