Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism.
Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism.
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DOI：
10.1016/j.immuni.2016.02.019
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发表时间：
2016-03-15
期刊：
影响因子：
32.4
通讯作者：
Sonnenberg GF
中科院分区：
文献类型：
--
作者：
Fung TC;Bessman NJ;Hepworth MR;Kumar N;Shibata N;Kobuley D;Wang K;Ziegler CGK;Goc J;Shima T;Umesaki Y;Sartor RB;Sullivan KV;Lawley TD;Kunisawa J;Kiyono H;Sonnenberg GF
哺乳动物免疫系统和共生细菌之间的物理分离对于限制慢性炎症是必要的。然而，有选择性的共生细菌可以在健康哺乳动物的肠道相关淋巴组织中存活。在这里，我们证明了淋巴组织常驻共生细菌（LRC）定植小鼠树突状细胞并调节其细胞因子的产生。在无菌和抗生素处理的小鼠中，lrc定植于肠道相关淋巴组织，并诱导多种IL-10细胞因子家族成员，包括树突状细胞衍生的IL-10和第3组先天淋巴细胞（ILC3）衍生的IL-22。值得注意的是，IL-10限制了促炎Th17细胞反应的发展，IL-22的产生在稳态下增强了LRC的定植。此外，LRC定植以il -10- il - 10r依赖的方式保护小鼠免受致死性肠道损伤。总的来说，我们的数据揭示了一种独特的宿主-共生细菌对话，其中共生细菌的选择性亚群与树突状细胞相互作用，以促进对宿主和微生物都有利的组织特异性反应。
Physical separation between the mammalian immune system and commensal bacteria is necessary to limit chronic inflammation. However, selective species of commensal bacteria can reside within intestinal-associated lymphoid tissues of healthy mammals. Here, we demonstrate that lymphoid tissue-resident commensal bacteria (LRC) colonized murine dendritic cells and modulate their cytokine production. In germ-free and antibiotic-treated mice, LRCs colonized intestinal-associated lymphoid tissues and induced multiple members of the IL-10 cytokine family, including dendritic cell-derived IL-10 and group 3 innate lymphoid cell (ILC3)-derived IL-22. Notably, IL-10 limited the development of pro-inflammatory Th17 cell responses, and IL-22 production enhanced LRC colonization in the steady state. Furthermore, LRC colonization protected mice from lethal intestinal damage in an IL-10-IL-10R-dependent manner. Collectively, our data reveal a unique host-commensal bacteria dialogue whereby selective subsets of commensal bacteria interact with dendritic cells to facilitate tissue-specific responses that are mutually beneficial for both the host and the microbe.