Defensins and cathelicidins in inflammatory lung disease: beyond antimicrobial activity
Defensins and cathelicidins in inflammatory lung disease: beyond antimicrobial activity
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DOI：
10.1042/bst0340276
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发表时间：
2006-04-01
影响因子：
3.9
通讯作者：
Hiemstra, PS
中科院分区：
文献类型：
--
作者：
Hiemstra, PS
先天免疫力是抵抗感染的有效第一道防线。这在肺中特别重要，肺是暴露于大量吸入的病原体的器官。抗菌肽作为天然免疫的效应分子在抵抗这些病原体中发挥重要作用。这些肽主要由吞噬细胞和上皮细胞产生，并杀死广泛的微生物：革兰氏阴性和革兰氏阳性细菌，真菌和（包膜）病毒。然而，越来越明显的是，这些肽不仅作为内源性抗生素，而且还显示出一系列其他功能，包括参与调节免疫反应和炎症以及伤口修复的活性。在这篇综述中，这些活动被强调，并讨论了它们在炎症性肺病中的作用。
Innate immunity provides an effective first line of defence against infections. This is of particular importance in the lung, an organ that is exposed to a large number of pathogens that are inhaled. Antimicrobial peptides play an important role in the defence against these pathogens as effector molecules of innate immunity. These peptides are mainly produced by phagocytes and epithelial cells, and kill a wide range of micro-organisms: Gram-negative and Gram-positive bacteria, fungi and (enveloped) viruses. However, it is increasingly evident that these peptides not only act as endogenous antibiotics, but also display a range of other functions, including activities that are involved in regulating immune responses and inflammation, and wound repair. in this review, these activities are highlighted and their role in inflammatory lung disorders is discussed.