Controlled release from coated polymer microparticles embedded in tissue-engineered scaffolds
Controlled release from coated polymer microparticles embedded in tissue-engineered scaffolds
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DOI：
10.3109/10611860108998777
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发表时间：
2001-01-01
影响因子：
4.5
通讯作者：
Marra, KG
中科院分区：
文献类型：
--
作者：
Hu, Y;Hollinger, JO;Marra, KG
人们正在研究组织工程植入物中蛋白质的控制释放，并将其应用于改善血管形成和加速组织生长。将牛血清白蛋白(BSA)包裹在聚(D，L-乳酸-乙醇酸)[PLGA]微球中。在制备过程中，将微粒包覆在聚乙烯醇上，并将其复合到PLGA组织工程支架中。测定了PLGA微球、包裹的PLGA微球和植入多孔PLGA支架的微球中牛血清白蛋白的释放。我们已经开发了一种新的方法，可以在PLGA支架制造过程中加入包覆的聚合物微粒。生长因子或药物可以被加入到微粒中，从而产生长期的、受控的释放。
The controlled release of proteins in tissue-engineered implants is being examined with the potential application to improve vascularization and hasten tissue growth. Bovine serum albumin (BSA), was encapsulated within poly(D,L-lactic-co-glycolic acid) [PLGA] microparticles. The microparticles were coated with poly(vinyl alcohol) and incorporated into PLGA tissue-engineered scaffolds during fabrication. The release of BSA from PLGA microparticles, coated PLGA microparticles, and microparticles embedded in a porous PLGA scaffold was measured. We have developed a novel approach that will permit incorporation of coated polymeric microparticles during PLGA scaffold fabrication. Growth factors or drugs could be incorporated into the microparticles resulting in a long-term, controlled release.