PERIOD OF SUSCEPTIBILITY TO PHYSIOLOGICAL EFFECTS OF UNILATERAL EYE CLOSURE IN KITTENS
PERIOD OF SUSCEPTIBILITY TO PHYSIOLOGICAL EFFECTS OF UNILATERAL EYE CLOSURE IN KITTENS
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DOI：
10.1113/jphysiol.1970.sp009022
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发表时间：
1970-01-01
影响因子：
5.5
通讯作者：
WIESEL, TN
中科院分区：
文献类型：
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作者：
HUBEL, DH;WIESEL, TN
1.通过在不同年龄段的不同时间内遮盖右眼的眼睑来剥夺小猫的视觉。随后，研究人员从纹状皮质中进行了记录，并对两只眼睛的反应进行了比较。如前所述，在生命的最初几个月，单眼闭眼会导致受先前闭眼影响的细胞数量急剧下降。对闭眼影响的敏感性在第四周开始时突然开始，直到第六周和第八周之间的某个时候一直很高，然后下降，最后在第三个月结束时消失。成年猫单眼闭眼一年以上不会产生可检测到的影响。在第四周和第五周的高敏感性期间，闭眼3 - 4天会导致双眼可驱动的细胞数量急剧下降，以及先前闭眼的相对影响的总体下降。6天的闭合足以使闭合的眼睛可以驱动的细胞数量减少到正常的一小部分。其生理情况类似于出生后3个月单眼剥夺，其中眼睛可以影响的细胞比例从85%下降到约7%。剥夺3 ~ 6天后，外侧膝状体接受剥夺眼输入的细胞在第4周明显变小，尼氏染色变淡。单眼剥夺3个月后，睁开眼睛长达5年，仅产生非常有限的恢复皮质生理，膝状体萎缩没有明显的恢复，即使在行为上有一些恢复的视力在剥夺的眼睛。闭上正常的眼睛，虽然对行为恢复是必要的，但对皮层生理学没有可检测的影响。如果闭眼时间限制在几周内，纹状皮质的可能恢复量可能不会更大，但在5周的闭眼后，恢复明显增强，尽管还远未完全恢复。
1. Kittens were visually deprived by suturing the lids of the right eye for various periods of time at different ages. Recordings were subsequently made from the striate cortex, and responses from the two eyes compared. As previously reported, monocular eye closure during the first few months of life causes a sharp decline in the number of cells that can be influenced by the previously closed eye.2. Susceptibility to the effects of eye closure begins suddenly near the start of the fourth week, remains high until some time between the sixth and eighth weeks, and then declines, disappearing finally around the end of the third month. Monocular closure for over a year in an adult cat produces no detectable effects.3. During the period of high susceptibility in the fourth and fifth weeks eye closure for as little as 3‐4 days leads to a sharp decline in the number of cells that can be driven from both eyes, as well as an over‐all decline in the relative influence of the previously closed eye. A 6‐day closure is enough to give a reduction in the number of cells that can be driven by the closed eye to a fraction of the normal. The physiological picture is similar to that following a 3‐month monocular deprivation from birth, in which the proportion of cells the eye can influence drops from 85 to about 7%.4. Cells of the lateral geniculate receiving input from a deprived eye are noticeably smaller and paler to Nissl stain following 3 or 6 days' deprivation during the fourth week.5. Following 3 months of monocular deprivation, opening the eye for up to 5 yr produces only a very limited recovery in the cortical physiology, and no obvious recovery of the geniculate atrophy, even though behaviourally there is some return of vision in the deprived eye. Closing the normal eye, though necessary for behavioural recovery, has no detectable effect on the cortical physiology. The amount of possible recovery in the striate cortex is probably no greater if the period of eye closure is limited to weeks, but after a 5‐week closure there is a definite enhancement of the recovery, even though it is far from complete.