Immunostimulatory-sequence DNA is an effective mucosal adjuvant.
Immunostimulatory-sequence DNA is an effective mucosal adjuvant.
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免疫刺激序列 DNA 是一种有效的粘膜佐剂。
DOI：
10.1007/978-3-642-59672-8_13
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发表时间：
2000
影响因子：
--
通讯作者：
Raz,E
中科院分区：
文献类型：
--
作者：
Horner,AA;Raz,E
呼吸道、胃肠道、阴道和直肠粘膜是感染因子和外来蛋白质进入的主要门户（CzerkinskyandHolmgren1995；StaatsandMcGhee1996）。粘膜组织和引流淋巴结内局部产生和分泌的免疫球蛋白 A (IgA) 和细胞毒性 T 淋巴细胞 (CTL) 可防止微生物感染（Gallichanet al. 1993；CzerkinskyandHolmgren1995；StaatsandMcGhee1996；AdaandMcElrath1997）。由于粘膜免疫系统在保护我们免受环境影响方面发挥着前线作用，因此人们对开发刺激保护性粘膜免疫反应的策略非常感兴趣。不幸的是，传统的疫苗接种方法并不有效，目前还没有简单、安全、普遍适用的方法来诱导粘膜免疫反应。
The respiratory, gastrointestinal, vaginal, and rectal mucosa are major portals of entry for infectious agents and foreign proteins (CzerkinskyandHolmgren1995;StaatsandMcGhee1996). Locally produced and secreted immunoglobulin A (IgA) and cytotoxic T lymphocytes (CTL) within the mucosal tissue and draining lymph nodes protect against microbial infection (Gallichanet al. 1993;CzerkinskyandHolmgren1995;StaatsandMcGhee1996;AdaandMcElrath1997). Because the mucosal immune system serves a front-line role in protecting us from our environment, there is a great deal of interest in developing strategies for stimulating protective mucosal immune responses. Unfortunately, traditional vaccination methods are not effective and, at present, there is no simple, safe, and generally applicable approach for the induction of mucosal immune responses.