Clozapine and body mass change
Clozapine and body mass change
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DOI：
10.1016/s0006-3223(97)00488-5
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发表时间：
1998-04-01
影响因子：
10.6
通讯作者：
Centorrino, F
中科院分区：
文献类型：
--
作者：
Frankenburg, FR;Zanarini, MC;Centorrino, F
背景：据报道，使用氯氮平治疗的患者体重会增加。我们假设患者也会经历体重增加，这可能更直接地与心血管疾病有关。方法：对42名接受氯氮平至少I级治疗的患者进行称重和测量，并计算腰臀比(WHR)和体重指数(BMI)，以kg/m(2)为单位。患者还被问及一系列可能与体重变化相关的因素。结果：女性患者的体重和体重都增加了。在氯氮平治疗37个月后，他们的腰围比为0.83，BMI从23.2公斤/米(2)显著增加到29.1公斤/米(2)(p=.001)，男性受试者的体重和体重也增加了。在氯氮平治疗39个月后，他们的腰围比为0.93，体重指数从26.4公斤/米(2)显著增加到29.7公斤/米(2)(p<；.001)。逐步多元回归分析显示，与终末体质量相关的因素有初始体质量、氯氮平剂量和吸烟减少。基线BMI对最终BMI的贡献最大，但剂量的增加和吸烟的减少对模型有显著贡献。结论：接受氯氮平治疗的女性和男性患者都增加了体质量。这可能会使他们面临更大的心血管疾病风险。(C)1998年生物精神病学学会。
Background: Patients treated with clozapine have been reported to gain weight. We hypothesized that patients would also experience an increase in body mass, which can be more directly related to cardiovascular morbidity.Methods: Forty-two patients who had been treated with clozapine for at least I gear were weighed and measrtred, and waist-hip ratios (WHR) and body mass index (BMI), measured as kg/m(2), were calculated. Patients were also asked about a series of factors potentially related to change in body mass.Results: Female patients gained both weight and body mass. Their WHR after 37 months of clozapine therapy was .83, with a significant increase in BMI from 23.2 to 29.1 kg/m(2) (p = .001), Male subjects also gained weight and body mass. Their WHR after 39 months of clozapine therapy was .93, with a significant increase in BMI from 26.4 to 29.7 kg/m(2) (p < .001). Stepwise multiple-regression analysis showed that factors related to final body mass were initial body mass, dose of clozapine, and decrease in smoking. Baseline BMI contributed most to the final BMI, but the addition of dose and decrease in smoking made significant contributions to the model.Conclusions: Both female and male patients treated with clozapine gain body mass. This may place them at greater risk for cardiovascular morbidity. (C) 1998 Society of Biological Psychiatry.