FRACTAL DESCRIPTION OF CEREBRAL CORTICAL PATTERNS IN FRONTAL-LOBE EPILEPSY
FRACTAL DESCRIPTION OF CEREBRAL CORTICAL PATTERNS IN FRONTAL-LOBE EPILEPSY
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DOI：
10.1159/000117155
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发表时间：
1995-11-01
影响因子：
2.4
通讯作者：
STEVENS, JM
中科院分区：
文献类型：
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作者：
COOK, MJ;FREE, SL;STEVENS, JM
正常大脑皮层的复杂结构无法用欧几里得几何来描述。然而，细微的异常往往在体内无法识别，可能是广泛的神经系统疾病的基础。皮质形态学的异常经常导致这些病变，我们应用分形几何学试图量化这些异常。我们已经证明了轴向和冠状面MR图像上皮质-白质界面的典型分形标度特性，正常受试者的分形维数（D-f）为1.45 ± 0.06（平均值+1标准差）。我们还将其应用于16例额叶癫痫患者，这是一种与皮质带的细微破坏相关的疾病，所有这些患者在视觉检查图像时都没有明显的异常。这16人中有9人有D-f
The convoluted pattern of normal cerebral cortex resists description by Euclidean geometry. However, subtle abnormalities often unrecognised in vivo may underlie a wide range of neurological disorders. Abnormalities of cortical morphology frequently characterise these lesions, and we applied fractal geometry in an attempt to quantify these abnormalities. We have demonstrated typical fractal scaling properties for the cortical-white matter interface on axial and coronal MR images, with a fractal dimension (D-f) of 1.45 + 0.06 (mean + 1 standard deviation) in normal subjects. We have also applied this to 16 patients with frontal lobe epilepsy, a condition associated with subtle disruptions of the cortical ribbon, all of whom had no obvious abnormality on visual inspection of the images. Nine of these 16 had a D-f