Tubulin synthesis during a critical period in visual cortex development
Tubulin synthesis during a critical period in visual cortex development
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视觉皮层发育关键时期的微管蛋白合成
DOI：
10.1016/0006-8993(78)90646-7
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发表时间：
1978
期刊：
影响因子：
2.9
通讯作者：
J. Cronly
中科院分区：
文献类型：
--
作者：
G. Perry;J. Cronly
我们之前曾报道过 2, 3 正常饲养的挪威黑冠大鼠睁眼后，视觉皮层中微管蛋白的合成会短暂增加。随后有人提出，微管蛋白合成的短暂升高可能是由睁眼引起的膝节节纤维神经电活动的变化引发的。此外，微管蛋白合成增加的阶段可能与视觉皮层发育的关键时期相对应3。本研究旨在测试这些建议。我们首先描述了黑暗饲养对视觉皮层微管蛋白合成的影响，并报告了黑暗饲养动物的微管蛋白合成如何受到24小时暴露于光照环境的影响。这里的目的是确定微管蛋白对光照反应的敏感性是否随动物的成熟状态和出生后年龄而变化。
We have previously reported 2, 3 that eye opening in normal hght-reared Norwegian black hooded rats, is followed by a transient rise in tubulin synthesis in the visual cortex. It was suggested then that the brief elevation in tubulin synthesis was perhaps triggered by the changes in neuroelectric activity in geniculostnate fibres brought about by eye opening; also, that the phase of increased tubulin synthesis might correspond with a critical period in visual cortical development 3. The present study set out to test these suggestions.We first describe the effect of dark rearing on tubulin synthesis in the visual cortex and also report on how tubulin synthesis in dark-reared animals is affected by a 24-h exposure to a lighted environment. The aim here was to ascertain if sensitivity of the tubulin response to light exposure varies with the animal's state of maturation and postnatal age.