Impaired neural response to speech edges in dyslexia
Impaired neural response to speech edges in dyslexia
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DOI：
10.1016/j.cortex.2020.09.033
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发表时间：
2021-02-01
期刊：
影响因子：
3.6
通讯作者：
Molinaro, Nicola
中科院分区：
文献类型：
--
作者：
Lizarazu, Mikel;Lallier, Marie;Molinaro, Nicola
语音理解已被提出严重依赖于振荡皮层跟踪，即神经振荡与语音的缓慢时间调制（包络）的相位对齐。 Speech-brain entrainment is readjusted over time as transient events (edges) in speech lead to speech-brain phase realignment. Auditory behavioral research suggests that phonological deficits in dyslexia are linked to difficulty in discriminating speech edges. Importantly, research to date has not specifically examined neural responses to speech edges in dyslexia. In the present study, we used MEG to record brain activity from normal and dyslexic readers while they listened to speech.我们计算锁相值（PLV）来评估神经振荡和时间锁定到边缘起始的语音包络之间的相位夹带。在两组中，我们观察到边缘起始在跟踪语音的听觉振荡中引起相位重置，从而增强了它们对语音的夹带。重要的是，与正常读者相比，有阅读困难的读者在边缘出现后的左听觉区域显示出更弱的 PLV，从大约 15 秒到大约 65 秒。 Our results indicate that the neural mechanism that adapts cortical entrainment to the speech envelope is impaired in dyslexia.这些发现与发展性阅读障碍的时间抽样理论一致。 (C) 2020 Elsevier Ltd. 保留所有权利。
Speech comprehension has been proposed to critically rely on oscillatory cortical tracking, that is, phase alignment of neural oscillations to the slow temporal modulations (envelope) of speech. Speech-brain entrainment is readjusted over time as transient events (edges) in speech lead to speech-brain phase realignment. Auditory behavioral research suggests that phonological deficits in dyslexia are linked to difficulty in discriminating speech edges. Importantly, research to date has not specifically examined neural responses to speech edges in dyslexia. In the present study, we used MEG to record brain activity from normal and dyslexic readers while they listened to speech. We computed phase locking values (PLVs) to evaluate phase entrainment between neural oscillations and the speech envelope time-locked to edge onsets. In both groups, we observed that edge onsets induced phase resets in the auditory oscillations tracking speech, thereby enhancing their entrainment to speech. Importantly, dyslexic readers showed weaker PLVs compared to normal readers in left auditory regions from similar to.15 sec to similar to.65 sec after edge onset. Our results indicate that the neural mechanism that adapts cortical entrainment to the speech envelope is impaired in dyslexia. These findings here are consistent with the temporal sampling theory of developmental dyslexia. (C) 2020 Elsevier Ltd. All rights reserved.