Enriching the diet with menhaden oil improves peripheral neuropathy in streptozotocin-induced type 1 diabetic rats
Enriching the diet with menhaden oil improves peripheral neuropathy in streptozotocin-induced type 1 diabetic rats
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DOI：
10.1152/jn.00718.2014
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发表时间：
2015-02-01
影响因子：
2.5
通讯作者：
Yorek, Mark A.
中科院分区：
文献类型：
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作者：
Coppey, Lawrence J.;Davidson, Eric P.;Yorek, Mark A.
本研究的目的是确定在 1 型糖尿病大鼠的饮食中补充鲱鱼油对糖尿病神经病变的影响。鲱鱼油是 n-3 脂肪酸的天然来源，已被证明对心血管疾病和其他疾病具有有益作用。使用链脲佐菌素诱导的糖尿病大鼠来检查在饮食中添加 25% 鲱鱼油对糖尿病神经病变的影响。同时使用了预防和干预方案。终点包括运动和感觉神经传导速度、热和机械敏感性以及角膜和后爪的神经支配和敏感性。根据所述终点评估，糖尿病神经病变被发现是进行性的。鲱鱼油不会改善升高的 HbA(1)C 水平或血清脂质水平。持续 16 周的糖尿病大鼠出现热痛觉减退，运动和感觉神经传导速度降低，角膜和皮肤的神经支配和敏感性受损。在预防或干预方案之后，使用鲱鱼油治疗可显着改善这些终点。我们发现，在 1 型糖尿病大鼠的饮食中补充鲱鱼油可以改善与糖尿病神经病变相关的多种终点。这些结果表明，富含 n-3 脂肪酸的饮食可能是糖尿病神经病变的良好治疗策略。
The purpose of this study was to determine the effect of supplementing the diet of type 1 diabetic rats with menhaden oil on diabetic neuropathy. Menhaden oil is a natural source for n-3 fatty acids, which have been shown to have beneficial effects in cardiovascular disease and other morbidities. Streptozotocin-induced diabetic rats were used to examine the influence of supplementing their diet with 25% menhaden oil on diabetic neuropathy. Both prevention and intervention protocols were used. Endpoints included motor and sensory nerve conduction velocity, thermal and mechanical sensitivity, and innervation and sensitivity of the cornea and hindpaw. Diabetic neuropathy as evaluated by the stated endpoints was found to be progressive. Menhaden oil did not improve elevated HbA(1)C levels or serum lipid levels. Diabetic rats at 16-wk duration were thermal hypoalgesic and had reduced motor and sensory nerve conduction velocities, and innervation and sensitivity of the cornea and skin were impaired. These endpoints were significantly improved with menhaden oil treatment following the prevention or intervention protocol. We found that supplementing the diet of type 1 diabetic rats with menhaden oil improved a variety of endpoints associated with diabetic neuropathy. These results suggest that enriching the diet with n-3 fatty acids may be a good treatment strategy for diabetic neuropathy.