CONJUGATIVE PLASMIDS IN BACTERIA OF THE PRE-ANTIBIOTIC ERA
CONJUGATIVE PLASMIDS IN BACTERIA OF THE PRE-ANTIBIOTIC ERA
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DOI：
10.1038/302725a0
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发表时间：
1983-01-01
期刊：
影响因子：
64.8
通讯作者：
DATTA, N
中科院分区：
文献类型：
--
作者：
HUGHES, VM;DATTA, N
抗生素耐药性在引起人类和动物疾病的细菌中很常见，通常由质粒决定。在过去的 25 年中，此类质粒的流行率及其产生耐药性的药物范围大幅增加。许多实验室的工作已经清楚地表明，质粒已经获得了最终来源未知的抗性基因，作为插入其环状 DNA 的形式。自 20 世纪 40 年代引入抗生素以来，抗生素的大量使用可以解释获得此类基因的质粒的传播，但在抗生素广泛用于医学之前，人们对病原菌中质粒的发生率知之甚少。 E. D. G. Murray 从 1917 年到 1954 年收集了肠杆菌科菌株；我们现在报告说，其中 24% 编码用于将 DNA 从一种细菌转移到另一种细菌的信息。至少 19% 的菌株中，不携带抗生素抗性的接合质粒被转移到大肠杆菌 K-12 中。
Antibiotic resistance is common in bacteria that cause disease in man and animals and is usually determined by plasmids. The prevalence of such plasmids, and the range of drugs to which they confer resistance, have increased greatly in the past 25 yr. It has become clear from work in many laboratories that plasmids have acquired resistance genes, of ultimately unknown origin, as insertions into their circular DNA. The intensive use of antibiotics since their introduction in the 1940s can explain the spread of plasmids that have acquired such genes but little is known of the incidence of plasmids in pathogenic bacteria before the widespread use of antibiotics in medicine. E. D. G. Murray collected strains of Enterobacteriaceae from 1917 to 1954; we now report that 24% of these encode information for the transfer of DNA from one bacterium to another. From at least 19% of the strains, conjugative plasmids carrying no antibiotic resistance were transferred toEscherichia coliK-12.