Hyperhomocysteinemia in dementia
Hyperhomocysteinemia in dementia
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DOI：
10.1007/s007020070010
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发表时间：
2000-01-01
影响因子：
3.3
通讯作者：
Fuchs, D
中科院分区：
文献类型：
--
作者：
Leblhuber, F;Walli, J;Fuchs, D
高同型半胱氨酸血症是动脉粥样硬化性血管疾病的一个强有力的危险因素，血清同型半胱氨酸升高与维生素B缺乏相关。在这项初步研究中，在阿尔茨海默病患者和血管性痴呆患者中发现同型半胱氨酸水平显著升高，可能表明类似的病理生理途径。我们发现低叶酸浓度和高同型半胱氨酸浓度与认知能力下降之间存在显著相关性。补充叶酸可能是降低痴呆患者高半胱氨酸水平的一种廉价方法。
Hyperhomocysteinemia is a strong risk factor for atherosclerotic vascular disease, and elevated serum homocysteine is correlated with vitamin B deficiency. In this pilot study, significantly elevated homocysteine levels were found in patients with Alzheimer's disease as well as in patients with vascular dementia, probably indicating similar pathophysiological pathways. We found significant correlations between low folic acid concentrations as well as high homocysteine concentrations and cognitive decline. Supplementation with folic acid may be an inexpensive way to reduce elevated homocysteine levels in demented patients.