Enhancement of Nanozyme Permeation by Endovascular Interventional Treatment to Prevent Vascular Restenosis via Macrophage Polarization Modulation
Enhancement of Nanozyme Permeation by Endovascular Interventional Treatment to Prevent Vascular Restenosis via Macrophage Polarization Modulation
复制标题
血管内介入治疗增强纳米酶渗透，通过巨噬细胞极化调节预防血管再狭窄
DOI：
10.1002/adfm.202006581
复制
发表时间：
2020-09-22
影响因子：
19
通讯作者：
Zhang, Fan
中科院分区：
文献类型：
--
作者：
Feng, Lishuai;Dou, Chaoran;Zhang, Fan
血管内介入治疗后血管再狭窄的长期预后是临床环境中的一个关键挑战。活性氧（ROS）的过量产生是加重血管再狭窄的主要因素。目前对血管再狭窄的临床药物干预仍不令人满意。纳米酶具有清除活性氧的特性，已广泛应用于炎症相关疾病的治疗。然而，在大多数疾病中，血管内皮细胞屏障阻碍了静脉注射纳米材料的递送效率。本文提出了一种有效的治疗血管再狭窄的策略，即通过血管球囊损伤血管内介入治疗内皮细胞脱落，从而增强纳米酶在血管内膜的被动渗透和巨噬细胞的摄取，从而缓解体内长期血管再狭窄。进一步探讨巨噬细胞极化调节预防血管再狭窄的机制。内皮细胞脱落增强血管内介入治疗纳米颗粒血管渗透的有趣发现可能为纳米材料治疗其他疾病提供应用前景。
The long-term prognosis of vascular restenosis after endovascular interventional treatment is a critical challenge in a clinical setting. Over-production of reactive oxygen species (ROS) is a major factor to aggravate vascular restenosis. Current clinical pharmacological interventions for vascular restenosis are still unsatisfactory. Based on the intrinsic ROS scavenging properties, nanozymes have been widely applied in the treatment of inflammatory-related diseases. However, the vascular endothelial cell barrier hinder the delivery efficiency of intravenously injected nanomaterials in most diseases. Herein, an effective therapeutic strategy for vascular restenosis is developed based on endothelial cells exfoliation by endovascular interventional treatment through vascular balloon injury, which provides an opportunity to enhance nanozyme passive permeation into the vascular intima and uptake by macrophages to alleviate long-term vascular restenosis in vivo. Moreover, the macrophages polarization modulation mechanism of vascular restenosis prevention is further investigated. This interesting discovery that endothelial cells exfoliation enhanced nanoparticle vascular permeation by endovascular interventional treatment may provide applicative perspectives in the treatment of other disease by nanomaterials.