Effects of Humoral Immunity and Calreticulin Overexpression on Postoperative Course in Breast Cancer
Effects of Humoral Immunity and Calreticulin Overexpression on Postoperative Course in Breast Cancer
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DOI：
10.1007/s12253-008-9112-2
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发表时间：
2009-03-01
影响因子：
2.8
通讯作者：
Vojinovic-Golubovic, Vesna
中科院分区：
文献类型：
--
作者：
Eric, Aleksandra;Juranic, Zorica;Vojinovic-Golubovic, Vesna
目的是探讨术前确定的肿瘤组织体液免疫和钙调蛋白过表达是否与乳腺癌患者术后两年内转移发生率相关。术前采用免疫化学方法检测两组患者的体液免疫及肿瘤组织中calticulin和Her-2/neu的过表达情况。在23例局部淋巴结转移患者中，7例Her-2/neu过表达。在这7例患者中，3例发生了远处转移（2例术后1年，1例术后2年），所有患者的肿瘤组织均表现出间质IgG免疫反应性和钙调钙蛋白的过度表达。初步数据显示，血清IgG对肿瘤基质的免疫反应性结合肿瘤细胞钙调蛋白的过表达与术后转移的出现相关，特别是Her-2/neu过表达肿瘤和腋窝淋巴结转移的患者。
The aim was to investigate whether the humoral immunity and overexpression of calreticulin in tumor tissue determined before surgery, correlate with incidence of metastases in breast cancer patients within two years after operation. Before operation, their humoral immunity and overexpression of caleticulin and Her-2/neu in tumor tissue were analyzed by immunohystochemistry. In 23 patients with metastases in regionally lymph nodes, seven had Her-2/neu overexpression. Among those seven patients, three developed distant metastasis (two women one year and in one woman two years after surgery) and all of them showed the presence of stromal IgG immunoreactivity and overexpression of calreticulin in their tumors tissue. Preliminary data showed that serum IgG immunoreactivity to tumor stroma in combination with overexpression of calreticulin in tumor cells correlate with postoperative appearance of metastases, particularly in the group of patients with Her-2/neu overexpressed tumors and metastases in axillary lymph nodes.